| 李娅娜,李 玲,江 山,王会会,谢红萍.丰富环境及康复训练对创伤性脑损伤大鼠神经功能恢复的影响[J].中国康复医学杂志,2013,28(5):393~397 |
| 丰富环境及康复训练对创伤性脑损伤大鼠神经功能恢复的影响 点此下载全文 |
| 李娅娜 李 玲 江 山 王会会 谢红萍 |
| 解放军总医院第一附属医院康复医学科，北京，100048 |
| 基金项目：国家自然科学基金资助项目（81071595；81201514） |
| DOI： |
| 摘要点击次数: 2063 |
| 全文下载次数: 2375 |
| 摘要： |
| 摘要
目的：研究丰富环境及康复训练对创伤性脑损伤大鼠神经功能恢复的影响。
方法：成年SD大鼠制作创伤性脑损伤大鼠模型，随机分为单纯脑损伤组、丰富环境组、行为训练组、运动训练组及综合康复训练组，每组10只，另设正常对照组10只。单纯脑损伤组不予任何处理，置于标准笼饲养；丰富环境组给予丰富环境笼饲养，不予训练；行为训练组给予水迷宫训练，置于标准笼饲养；运动训练组给予行走、平衡、抓握训练，置于标准笼饲养；综合康复训练组给予丰富环境笼饲养，并给予水迷宫及行走、平衡、抓握训练。各组大鼠于损伤后第3天、7天、14天、21天分别给予运动及学习记忆功能评定。
结果：脑损伤后第3天，各组大鼠的运动及学习记忆能力无显著性差异，均低于空白对照组（P＜0.05）。综合康复训练组大鼠的运动及学习记忆能力在训练第7天时明显改善，与空白对照组大鼠比较无显著性差异；而行为训练组大鼠的学习记忆能力也在第7天—第14天有显著改善，与对照组无明显差异；运动训练组与丰富环境组大鼠的学习记忆能力第21天开始也有明显好转，但均低于对照组（P＜0.05）。运动训练组大鼠的运动能力在第7天—第14天有显著改善，与对照组无明显差异；行为训练组与丰富环境组大鼠的运动能力第21天开始也有明显好转，但均低于对照组（P＜0.05）；单纯脑损伤组大鼠的运动及学习记忆能力未见有显著改善，低于对照组（P＜0.05）。
结论：丰富环境及康复训练可促进创伤性脑损伤大鼠运动及学习记忆功能的恢复。 |
| 关键词：创伤性脑损伤 丰富环境 康复训练 运动 学习记忆 |
| Effects of enriched environment and rehabilitation training on the recovery of neural function of rats with traumatic brain injury Download Fulltext |
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| First Affiliated Hospital of Chinese PLA General Hospital, Beijing, 100048 |
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| Abstract: |
| Abstract
Objective: To study the effect of enriched environment and rehabilitation training on the recovery of neural function of rats with traumatic brain injury.
Method: Sprague-Dawley adult male rats were made in traumatic brain injury model and then randomly assigned to model group, EE group, behavior training group, exercise group and comprehensive rehabilitation training group. Another ten rats were as normal group. The rats in the model group were feed in cages while those in the EE group were feed in enriched environment cages, both of them were not given training. The rats in behavior training group were given Morris water maze training while those in the exercise group were given balancing, grasping and walking exercises everyday. Both of them were feed in normal cages. The rats in comprehensive rehabilitation training group were feed in EE cages and given Morris water maze training, balancing, grasping and walking exercises everyday. The rats in the control group were without any treatment. Neural function test at the time points of 3, 7, 14, and 21 days.
Result: The neural function of rats with traumatic brain injury was no different and worse than those in the control group at the time of 3 days. The ability of movement, learning and memory of rats in comprehensive rehabilitation training group improved to normal level at the time of 7 days. The ability of learning and memory of rats in behavior training group was improved to normal level at the time of 14 days. The ability of learning and memory of rats in EE group and exercise group was better than before at the time of 21 days but also worse than those in the control group. The motor function of rats in behavior training group was improved to normal level at the time of 14 days. The motor function of rats in EE group and behavior training group was better than before at the time of 21 days but also worse than those in the control group. The neural function of rats in model group was no change and worse than those in the control group at the time points of 3, 7, 14, and 21 days.
Conclusion: Enriched environment and rehabilitation training can improve the ability of movement, learning and memory of rats with traumatic brain injury. |
| Keywords:traumatic brain injury enriched environment rehabilitation training movement learning and memory |
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