| 汪 洁,吴东宇,袁 英,闫彦宁,杨玉慧.前后语言区经颅直流电刺激对失语症图命名作用的比较[J].中国康复医学杂志,2018,(8):910~914 |
| 前后语言区经颅直流电刺激对失语症图命名作用的比较 点此下载全文 |
| 汪 洁 吴东宇 袁 英 闫彦宁 杨玉慧 |
| 首都医科大学宣武医院康复医学科，北京，100053 |
| 基金项目：国家自然科学基金资助课题（81171011、81272173、81572220），首都临床特色应用研究（Z121107001012144、Z171100001017028） |
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| 摘要
目的：探讨前后语言区经颅直流电刺激（transcranial direct current stimulation, tDCS）对左侧额颞或额颞顶脑卒中后失语症患者图命名的疗效，以及两个脑区tDCS治疗效果是否有差异。
方法：对左侧额颞或额颞顶脑卒中后4周—6个月的失语症患者20例，随机分为前语言区（Broca区）tDCS组和后语言区（Wernicke区）tDCS组各10例。Broca区组阳极tDCS放置于左侧Broca区，Wernicke区组阳极tDCS放置于左侧Wernicke区。采用A-B和B-C-A设计，A期为tDCS假刺激+语言治疗；B期为tDCS+语言治疗；C期为洗脱期1周。所有患者随机进入A-B或B-C-A期治疗。每个治疗期5天，每天2次。
结果：Wernicke区tDCS不但能提高治疗项，也能够提高非治疗项图命名成绩（P<0.05）；Broca区tDCS对图命名有改善，但未达到显著水平（P<0.08）。
结论：Wernicke区tDCS能更显著地改善脑卒中后额颞损伤失语症患者的图命名能力，其原因可能是后部语言区刺激涉及了Wernicke区及其邻近的语言相关脑区有关。 |
| 关键词：经颅直流电刺激 失语症 图命名 脑卒中 |
| A comparison between the effects of transcranial direct current stimulation over anterior and posterior language regions on picture naming in aphasia Download Fulltext |
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| Xuanwu Hospital of Capital Medical University, Beijing, 100053 |
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| Abstract: |
| Abstract
Objective: To investigate the effects of anodal tDCS over left Broca’s and Wernicke’s areas on picture naming in aphasic patients after stroke and compare the effects of two areas.
Method: Totally 20 aphasics with left frontotemporal or frontotemporal and parietal cortex lesions were randomly divided into Broca’s- and Wernicke’s-groups, with 10 subjects in each group. In Broca’s-group or Wernicke’s-group, an anodal tDCS was applied on left Broca’s area or left Wernicke’s area,respectively. An A-B and B-C-A designs were used in this study. Conventional language treatment coupled with sham tDCS was implemented for 1 weeks in phase A, the language treatment coupled with tDCS for 1 weeks in phase B and the language treatment as wash-out in phase C. All patients were randomly enrolled in the A-B or B-C-A. 5 days treatment was carried out in each phase, twice a day.
Result: In Wernicke-group, picture naming ability did not only improved in treatment items, but also un-treatment items (P<0.05), picture naming improved yet in Broca-group, but did not reach significant level (P<0.08).
Conclusion: Anodal tDCS over the left Wernicke’s area coupled with language treatment can improve picture naming and have a generalizing effect on untreated items in aphasic patients with left frontotemporal or frontotemporal and parietal cortex lesions. |
| Keywords:transcranial direct current stimulation aphasia picture naming stroke |
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