| 黄 传,万春晓,张嘉玮,孟祥雪,徐凯月,史 昱.8周不同运动干预对心肌梗死大鼠心功能的影响[J].中国康复医学杂志,2020,(8):926~931 |
| 8周不同运动干预对心肌梗死大鼠心功能的影响 点此下载全文 |
| 黄 传 万春晓 张嘉玮 孟祥雪 徐凯月 史 昱 |
| 天津医科大学总医院，天津市，300070 |
| 基金项目：天津市自然科学基金重点项目（18JCZDJC98900）；天津市卫生局重点发展项目（16KJ122） |
| DOI：10.3969/j.issn.1001-1242.2020.08.008 |
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| 摘要
目的:探究8周高强度间歇性运动（high intensity interval training， HIIT）、中等强度持续运动（continuous moderate-intensity training， CMT）、静息（sedentary， SED）干预对心肌梗死（myocardial infarction， MI）后心脏功能的影响及其分子机制。
方法:24只大鼠随机分为对照组（CON）、心梗静息组（MI-SED）、心梗CMT组（MI-CMT）、心梗HIIT组（MI-HIIT），分别进行8周干预，观察实验终点时左心室射血分数（left ventricular ejection fraction， LVEF）、心肌梗死面积比及过氧化物酶体增殖物激活受体γ辅激活因子1α（peroxisome proliferator-activated receptor gamma coactivator 1-alpha，PGC1-α）表达。
结果:干预8周后，①与MI-SED组比较，MI-CMT、MI-HIIT组梗死面积比均显著降低(14.93±1.934%， PMI-CMT=0.000; 16.72±1.125%， PMI-HIIT=0.000)；②MI-HIIT组大鼠LVEF显著低于MI-CMT组（37.15±7.141% VS 47.22±8.242%， P=0.017）；③MI-CMT、MI-HIIT组PGC1-α显著高于MI-SED组（PMI-CMT=0.019， PMI-HIIT=0.022）;④在MI-SED、MI-CMT、MI-HIIT组中，PGC1-α与LVEF呈正相关，而与梗死面积比呈负相关(P<0.05)。
结论:8周的CMT和HIIT效果均优于SED，CMT和HIIT可以激活PGC1-α的表达，改善心梗后的心肌纤维化程度，且8周的CMT干预保护并改善心功能的效果最佳。 |
| 关键词：心肌梗死 心脏康复 高强度间歇性运动 中等强度持续运动 |
| Effects of 8 weeks different exercise interventions on cardiac function in rats with myocardial infarction Download Fulltext |
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| Department of Physical Medicine and Rehabilitation， Tianjin Medical University General Hospital， Tianjin， 300070 |
| Fund Project: |
| Abstract: |
| Abstract
Objective: To explore the effects and molecular mechanism of 8 weeks high intensity interval training (HIIT)， moderate intensity-intensity training (CMT)， and sedentary (SED) intervention on cardiac function after myocardial infarction（MI）.
Method: Twenty-four rats were randomly divided into control group (CON)， MI plus SED intervention group (MI-SED)， MI plus CMT group (MI-CMT)， and MI plus HIIT group (MI-HIIT)， and interventions were performed for 8 weeks， respectively. At the end of the experiment， left ventricular ejection fraction (LVEF)， infarction area ratio， and peroxisome proliferator-activated receptor gamma coactivator 1- Alpha (PGC1-α) expression were observed.
Result: After 8 weeks of intervention， compared with MI-SED group， the infarction area ratio of MI-CMT and MI-HIIT group were significantly lower (14.93±1.934%， PMI-CMT=0.000; 16.72±1.125%， PMI-HIIT=0.000); LVEF in the MI-HIIT group was significantly lower than that in the MI-CMT group (37.15±7.141% vs 47.22±8.242%， P=0.017); In MI-CMT and MI-HIIT group，PGC1-α level was significantly higher than MI-SED group (PMI-CMT=0.019，PMI-HIIT=0.022); In MI-SED， MI-CMT， MI-HIIT group， PGC1-α level was positively correlated with LVEF，while there was a negative correlation between PGC1-α level and the infarct size ratio(P<0.05).
Conclusion: 8 weeks of CMT and HIIT had better effects than 8 weeks of SED. Both CMT and HIIT can activate the expression of PGC1-α and reduce the degree of myocardial fibrosis after myocardial infarction，and CMT intervention for 8 weeks is better in protecting and improving cardiac function. |
| Keywords:myocardial infarction cardiac rehabilitation high intensity interval training continuous moderate-intensity training |
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