| 田 鹏,师捷璇,马 娇,李海鹏.不同运动方式对青年期和老年期SAMP8小鼠胫骨前肌氧化应激影响的研究[J].中国康复医学杂志,2020,(12):1416~1421 |
| 不同运动方式对青年期和老年期SAMP8小鼠胫骨前肌氧化应激影响的研究 点此下载全文 |
| 田 鹏 师捷璇 马 娇 李海鹏 |
| 山西大学商务学院，山西省太原市，030031 |
| 基金项目：山西省基础研究计划面上项目（201601D021100） |
| DOI：10.3969/j.issn.1001-1242.2020.12.002 |
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| 摘要： |
| 摘要
目的：研究抗阻运动和有氧运动对青年期和老年期雄性SAMP8小鼠胫骨前肌组织氧化应激水平的影响。
方法：选择青年期（3月龄）和老年期（6月龄）健康雄性SAMP8小鼠随机分为对照组、抗阻运动组和有氧运动组，进行为期8周运动训练后检测各组小鼠胫骨前肌丙二醛（MDA）含量、总抗氧化能力（T-AOC）、超氧化物歧化酶（SOD）和过氧化氢酶（CAT）活性。
结果：抗阻运动干预后老年期小鼠胫骨前肌中MDA的降低（P＜0.05），而有氧运动干预可导致青年期小鼠MDA含量降低（P＜0.05）；不同运动方式干预后老年期小鼠T-AOC值均降低（P＜0.05），而青年期抗阻运动和有氧运动组小鼠T-AOC值均升高（P＜0.05），增幅分别为22%和44%；有氧运动干预后，老年期和青年期小鼠胫骨前肌SOD和CAT活性均显著高于各自对照组和抗阻运动组（P＜0.05）。
结论：青年期小鼠以增强抗氧化能力的方式缓解氧化应激，且有氧运动要比抗阻运动效果明显；而老年期小鼠则可能是以激发免疫系统的急性响应为主，但过量的机械负荷导致其总抗氧化能力下调。 |
| 关键词：抗阻运动 有氧运动 氧化应激 SAMP8小鼠 自由基 |
| Study of different exercises on oxidative stress in anterior tibial muscle of young and aged SAMP8 mice Download Fulltext |
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| School of Commerce, Shanxi University, Shanxi, Taiyuan, 030031 |
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| Abstract: |
| Abstract
Objective: The resistance exercise and aerobic exercise were carried out on young and aged SAMP8 mice to study the effects of exercises intervention on oxidative stress levels in anterior tibial muscle of mice hindlimb.
Method: Young (three-month-old) and older (six-month-old) healthy male SAMP8 mice were randomly divided into control groups, resistance exercise groups and aerobic exercise groups, respectively. After 8-week exercise training, the levels of malondialdehyde (MDA), the total antioxidant capacity (T-AOC), superoxide dismutase (SOD) activities, and catalase (CAT) activities in anterior tibial muscle of mice hindlimb were detected.
Result: Decreased MDA levels in anterior tibial muscle of aged mice in resistance exercise groups was observed（P＜0.05）, and the MDA levels of young mice in aerobic exercise groups were significantly downregulated（P＜0.05）. Both exercise intervention modes significantly reduced the T-AOC levels of aged mice（P＜0.05）, but the T-AOC levels of young mice in resistance exercise and aerobic exercise groups were increased significantly by 22% and 44%（P＜0.05）. The detecting of SOD and CAT activities in aged and young mice showed that both enzymes activities of aerobic exercise groups were significantly higher than that of control and resistance exercise groups（P＜0.05）.
Conclusion: Young mice relieve oxidative stress mainly by enhancing antioxidant capacity, and aerobic exercise is more effective than resistance exercise. The old mice reduce oxidative damage mainly by stimulating the acute response of immune system, but the excessive exercise still resulted in the decreased total antioxidant capacity. |
| Keywords:resistance exercise aerobic exercise oxidative stress SAMP8 mice free radicals |
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