| 胡静璐,郭冬菊,王德正,徐舫舟,张 杨,岳寿伟.基于脑电信号的上肢运动想象与运动执行脑网络的动态功能连接研究[J].中国康复医学杂志,2024,(3):326~333 |
| 基于脑电信号的上肢运动想象与运动执行脑网络的动态功能连接研究 点此下载全文 |
| 胡静璐 郭冬菊 王德正 徐舫舟 张 杨 岳寿伟 |
| 山东大学齐鲁医院康复科，山东省济南市，250012 |
| 基金项目：山东省自然科学基金面上项目（ZR202102200383）；2019年山东省高等学校青创科技计划项目（2019KJN010）；国家自然科学基金面上项目（82172535）；山东省重大科技创新工程项目（2019JZZY011112） |
| DOI：10.3969/j.issn.1001-1242.2024.03.004 |
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| 摘要： |
| 摘要
目的：本研究通过记录脑卒中偏瘫患者及健康人进行指定的运动想象（motor imagery， MI）及运动执行时的脑电信号，评估不同任务态初级运动区（motor area， M1）及运动前区（premotor area， PMA）相关节点的功能连接的差异，并探索其与共同运动、分离运动控制之间的关系。
方法：共纳入10例脑卒中偏瘫患者及19例健康人，所有受试者根据视觉指令完成运动想象与运动执行任务，采集执行任务时的脑电信号，选取包括M1和PMA上的12个信道数据进行分析。对8—30Hz频带脑电信号进行滤波处理，采用基于改良S变换提取特征，并进行归一化处理避免个体差异，分别对左右手运动想象以及两种运动执行时12个节点的数据进行相关性分析（Pearson相关系数）以明确脑功能连接，并对节点度进行χ2检验观察差异。
结果：在脑卒中患者中，各节点关联度在运动想象及运动执行中的分布趋势与健康人类似；与运动执行相比，运动想象时各节点功能连接强度和密度都有升高趋势，与健康人结果类似。健康人在进行左手运动想象时，M1区的C4节点关联度明显高于对侧C3（P<0.05），当右手运动想象时，在左侧PMA区FC3和FC1的功能连接总和明显高于对侧FC4和FC2总和（P<0.05）；当进行右上肢分离运动时，C3节点度明显降低（P<0.05）。
结论：右手运动想象的功能连接的核心区域在左侧PMA区，且各信道节点关联度高于运动执行，而左手运动想象功能连接分布较平均。共同运动与分离运动模式所激活的主要脑区存在差异。 |
| 关键词：运动执行 运动想象 功能连接 相关性分析 分离运动 |
| The dynamic functional connectivity of brain network during motor imagination and execution of upper limbs based on EEG signals Download Fulltext |
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| Qilu Hospital， Cheeloo College of Medicine， Shandong University， Jinan， 250012 |
| Fund Project: |
| Abstract: |
| Abstract
Objective： The electroencephalogram （EEG） signals were collected for analysis to define the differences in dynamic functional connectivity of the brain network of related nodes in the primary motor area （M1） and premotor area （PMA） during motor imagination and motor execution. The relationship between muscle synergy and isolated movement was also explored.
Method： Ten stroke patients with right hemiplegia and nineteen healthy adults participated in this study. All participants performed motor imagination （MI） and motor execution （ME） tasks according to visual instructions. We recorded and analyzed the EEG signals at 12 sites located in M1 and PMA areas. The chosen EEG signals were filtered and analyzed based on the modified S-transform （MST）. All data were normalized to avoid individual differences. Then we analyzed the data with Pearson correlation to identify the dynamic functional connectivity （FC） and the differences with Fisher’s exact test for node degrees.
Result： All the distribution trend of correlation degree of chosen node about left or right MI and ME of stroke patients was similar to that of healthy participants. Compared with the motion execution， the function connection strength and density of each node were elevated at MI， which was also consistent with healthy participants. When healthy adults underwent left hand MI， the degree of the C4 node in the M1 area was significantly higher than that of C3 on the opposite side （P<0.05），while at right hand MI， the sum of the node degrees of FC3 and FC1 in the left PMA area was significantly higher than that of the lateral symmetric channel FC4 and FC2 （P<0.05）. When the right upper limb isolated movement was performed， the node degree of C3 decreased significantly （P<0.05）.
Conclusion： The major region of function connectivity of the right hand MI was in the left PMA area， and the node degree at MI was higher than ME. The functional connectivity of each node at the left hand MI was dispersed. The main channels activated by the muscle synergy are different from the isolated movement. |
| Keywords:motor execution motor imagination functional connectivity pearson correlation isolated movement |
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