| 刘雷,裴福兴,唐康来,许建中,李起鸿.碱性成纤维细胞生长因子对大鼠牵张性脊髓损伤后脊髓功能影响的研究[J].中国康复医学杂志,2005,20(1):18~19 |
| 碱性成纤维细胞生长因子对大鼠牵张性脊髓损伤后脊髓功能影响的研究 点此下载全文 |
| 刘雷 裴福兴 唐康来 许建中 李起鸿 |
| [1]第三军医大学西南医院骨科．重庆．400038 [2]四川大学华西医院骨科 |
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| 摘要： |
| 目的：观察bFGF对大鼠牵张性脊髓损伤后脊髓功能恢复的作用。方法：大鼠脊髓T13-L2经牵张损伤．皮层体感诱发电位CSEP监测P1-N1波幅下降至术前波幅70％后，于损伤平面以下经蛛网膜下腔置细导管，治疗组分别于即刻、1、2、3、4、8、12、24h经细导管注入bFGF溶液20μl(含bFGF20μg)，对照组在相同时间注入等量生理盐水。术后1、2、3、6周进行联合行为评分及CSEP检查。结果：bFGF治疗组大鼠CBS评分、CSEP波幅及潜伏期恢复均好于对照组。结论：bFGF对大鼠牵张损伤脊髓的功能恢复有明显的促进作用。 |
| 关键词：牵张性 脊髓损伤 皮层体感诱发电位 碱性成纤维细胞生长因子 |
| A study of the influence of bFGF on neural function after tractive spinal cord injury in rats Download Fulltext |
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| Abstract: |
| Objective:To observe the effect of bFGF on the recovery of neural function after tractive spinal cord injury in rats.Method:After T13-L2 were injured by traction a decreasing of the P1-N1 to 70% of the control through cortical somatosensory evoked potential with CSEP,and a thin plastic tube was into the subarachoid space below the injuried level for perfusion. The bFGF-treated rats were recived bFGF 20ug (20ul liquid) through the tube at once and 1?2?3?4?8?12and 24 hours after injury respectively.The saline-treated rats were received the equal volume of normal saline at the same time.After operation,rats were tested with combined behavioral score(CBS) and CSEP in 1?2?3?6 weeks. Result:CBS amplitude and latency of CSEP have better recovery in bFGF-treated group than in the control group.Conclusion:bFGF can promote markedly the recovery of neural function of tractive injuried spinal cord in rats. |
| Keywords:traction,spinal cord injury,cortical somatosensory evoked potential,basic fibroblast growth factor |
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