陈文学,廖维靖,刘华,白国允,岳勇,$2,$2,刘买利,叶朝辉.当归对大鼠缺血性脑损伤代谢物的影响[J].中国康复医学杂志,2006,21(10):879~882 |
当归对大鼠缺血性脑损伤代谢物的影响 点此下载全文 |
陈文学 廖维靖 刘华 白国允 岳勇 $2 $2 刘买利 叶朝辉 |
[1]中国科学院武汉物理与数学研究所,波谱与原子分子物理国家重点实验室,湖北武汉430071 [2]中国科学院研究生院,波谱与原子分子物理国家重点实验室,湖北武汉430071 [3]武汉大学中南医院,波谱与原子分子物理国家重点实验室,湖北武汉430071 |
基金项目:国家自然科学基金资助项目(10234070.20573132) |
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摘要: |
目的:观察大鼠缺血性脑损伤对大、小脑波谱的影响以及当归对大鼠缺血性脑损伤代谢物质的变化。方法:18只雄性Wistar大鼠,体重150-200g,随机分成正常对照组(n=6)、缺血组(n=6)、当归治疗组(n=6)。采用大脑中动脉阻断法(middle cerebral artery occlusion,MCAO)制作大鼠急性脑缺血损伤模型,缺血3h后,恢复血供或当归治疗,采用离体高分辨魔角旋转波谱(1^H HR MAS NMR)技术检测,观察大、小脑波谱中胆碱(Cho)、肌酸(Cre)、N-乙酰天门冬氨酸(NAA)、γ-氨基丁酸(GABA)、符氨酸(Glu)、天冬氨酸(Asp)、甘氨酸(Gly)等共振峰的变化。结果:除Cho,Glu,Asp升高,大鼠急性脑缺血时大多数代谢物含量均明显低于正常对照组.经当归治疗后其代谢物的含量会有所增加。结论:缺血严重影响大、小脑神经元的存活和物质代谢。当归对大鼠缺血性脑损伤具有明显的保护作用. |
关键词:核磁共振 魔角旋转 模式识别 脑缺血 当归 |
Effects of angelica on metabolites in cerebral ischemia rats Download Fulltext |
CHEN Wenxue LIAO Weijing LIU Hua et al. |
State Key Laboratory of Magnetic Resonance and Atomic Molecular and Physics,Wuhan Insti- tute of Physics and Mathematics,the Chinese Academy of Sciences,Wuhan,430071 |
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Abstract: |
Objective:To study the effect of angelica on metabolites in cerebral ischemia rats by high-resolution magic angle spinning HRMAS 1H nuclear magnetic resonance spectroscopy.Method:18 male Wistar rats,weighing 150-200g, were randomly divided into four groups such as normal(n=6),ischemia(n=6),Angelica treatment(n=6). The rat ischemia model was established by middle cerebral artery occlusion(MCAO) method,resuming blood or drug treatment after 3 hours ischemia. The metabolites changes of rat cerebra and cerebella was observed with 1H HRMAS NMR technology,including N-acetyl-aspartate(NAA),creatine(Cre),choline(Cho),glycine(Gly),glutamate(Glu),aspartate(Asp) and taurine(Tau) etc. Result:Excluding Cho,Glu,Asp,the concentrations of most metabolites of rat brain during ischemia were significantly lower than these of normal rats,and could be increased after drug treatment.Conclusion:Angelica shows positive effect on metabolites in cerebral ischemia rats. |
Keywords:nuclear magnetic resonance spectroscopy magic angle spinning pattern recognition ischemia angelica |
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