| 商永华,王群,陆兵勋,刘海云.慢性脑缺血大鼠学习记忆变化及甲状腺激素的影响[J].中国康复医学杂志,2007,22(3):209~211 |
| 慢性脑缺血大鼠学习记忆变化及甲状腺激素的影响 点此下载全文 |
| 商永华 王群 陆兵勋 刘海云 |
| 南方医科大学南方医院神经内科,广州510515 |
| 基金项目： |
| DOI： |
| 摘要点击次数: 2159 |
| 全文下载次数: 2031 |
| 摘要： |
| 目的：研究慢性脑缺血大鼠学习记忆的变化及甲状腺激素的影响。方法：成年SD大鼠随机分为假手术组10只；单纯双侧颈总动脉结扎手术组7只；术后甲状腺激素治疗组8只。各组于5周后采用Morris水迷宫测试大鼠学习记忆能力。结果：各组大鼠搜索策略趋向式和直线式所占比例比较：单纯手术组较假手术组、术后治疗组显著减少（P〈0．01），术后治疗组与假手术组之间差异无显著性意义；定位航行试验：单纯手术组较假手术组、术后治疗组逃避潜伏期明显延长（P〈0．05）；空间探索试验：单纯手术组较假手术组显著缩短（P〈0．01）。结论：慢性脑缺血大鼠学习记忆能力明显受损，甲状腺激素治疗可以使其学习能力得到明显改善，并在一定程度上提高其工作记忆功能。 |
| 关键词：血管性认知障碍 学习记忆 大鼠 甲状腺激素 |
| The changes of ability of learning and memory in rats with chronic cerebral ischemia and the effects of thyroid hormone Download Fulltext |
| SHANG Yonghua WANG Qun LU Bingxun et al |
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| Fund Project: |
| Abstract: |
| Objective:To study the changes ability of learning and memory in the rats with chronic cerebral ischemia and the effects of thyroid hormone. Method: Twenty-five male SD rats were randomly allocated into sham operation group(SO,n=10),operation group(PO,n=7),thyroid hormone treatment group(THT, n=8).Morris water maze test was performed at the end of experiment. Result:The average escape latency of PO rats was significantly longer than the other groups during platform orientation test(P<0.05). The probe time of the SO group was much shorter than the other two groups during spatial probe test (P<0.05). Conclusion:The ability of learning and memory of the rats with chronic cerebral ischemia was obviously impaired.Thyroid hormone can significantly improve the ability of learning,and the function of memory in some degree. |
| Keywords:vascular cognitive impairment learning and memory rat thyroid hormone |
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