| 任彩玲,李万伟,张钧.有氧运动对自发性高血压大鼠心肌BNP mRNA表达的影响[J].中国康复医学杂志,2007,22(8):699~701 |
| 有氧运动对自发性高血压大鼠心肌BNP mRNA表达的影响 点此下载全文 |
| 任彩玲 李万伟 张钧 |
| [1]赣南医学院运动人体科学系,江西省赣州341000 [2]潍坊医学院预防系,江西省赣州341000 [3]扬州大学体育学院,江西省赣州341000 |
| 基金项目：赣南医学院立项课题（2006062） |
| DOI： |
| 摘要点击次数: 2020 |
| 全文下载次数: 2026 |
| 摘要： |
| 目的：观察有氧运动对自发性高血压大鼠（SHR）心肌BNP mRNA表达的影响,探讨适宜的有氧运动对高血压性心肌肥大的防治作用及机制。方法：雄性Wistar大鼠6只为正常对照组（C组）,雄性SHR16只,随机分为高血压组（S组）和高血压运动组（T组）。T组每日进行60min无负重游泳,每周6次,共9周,用RT-PCR方法检测大鼠心脏BNP mRNA表达。结果：与C组相比,S组心肌BNP mRNA表达显著升高（P〈0.01）;与S组相比,T组心肌BNPmRNA表达非常显著降低（P〈0.01）。结论：长期规律的适宜运动可以明显降低SHR心肌BNPmRNA表达,改善由高血压引起的心肌肥大。 |
| 关键词：脑钠素 心肌肥大 运动 自发性高血压 |
| Aerobic exercise effects on expression of BNP protein in the cardiac muscle of spontaneous hypertension rats(SHR) Download Fulltext |
| REN Cailing LI Wanwei ZHANG Jun |
| Physical Department of Gannan Medical College,Ganzhou,341000 |
| Fund Project: |
| Abstract: |
| Objective:To investigate the effect of aerobic exercise on expression of BNP mRNA in the cardiac muscle of SHR. Method: The grouping and processions were as follows. Normal control group(C):6 male Wistar rats. SHR group(S): 8 male SHRs. Train SHR group(T):8 male SHRs. S group carried on 60 minutes unloaded swimming 6 times a week for 9 weeks. The rats in all groups were fed on normal feedstuff. After 9 weeks BNP mRNA was determined by RT-PCR. Result: The expression of BNP mRNA in S group exhibited a significant increase compared with normal control group (P<0.01);Compared with S group, the expression of BNP mRNA in T group descended obviously(P<0.01). Conclusion: The aerobic exercise can reduce the expression of BNP mRNA obviously improve the development of cardiac hypertrophy induced by hypertension. |
| Keywords:brain natriuretic peptid cardiac hypertrophy exercise spontaneous hypertension |
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