| 吴东宇,何 俊,杜巨豹,袁 英,刘 霖,宋为群.脑电非线性分析在意识障碍监测中的应用[J].中国康复医学杂志,2008,23(1):14~15 |
| 脑电非线性分析在意识障碍监测中的应用 点此下载全文 |
| 吴东宇 何 俊 杜巨豹 袁 英 刘 霖 宋为群 |
| 首都医科大学宣武医院康复科,北京, 100053;首都医科大学宣武医院康复科,北京, 100053 |
| 基金项目：国家自然科学基金资助课题（30600186） |
| DOI： |
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| 摘要： |
| 目的:探讨意识障碍患者脑电非线性动力学特性的变化规律，应用脑电非线性分析来定量评估其意识障碍程度。方法:本研究包含30例严重颅脑外伤或卒中的意识障碍患者，所有患者格拉斯哥昏迷评分量表（GCS）评分≤8分。依次采集患者安静闭眼、声音刺激和痛觉刺激三种状态下的脑电信号，并计算了三种状态下的脑电信号的关联维数、近似熵和复杂度非线性指数。结果:安静闭眼状态下，关联维数、近似熵和复杂度非线性指数分别保持在2.84、0.53、0.26的低水平，声音刺激和痛觉刺激与安静闭眼状态相比，脑电非线性指数几乎无变化。结论:脑电非线性分析能够实时监测和直接度量意识障碍患者大脑皮质受抑制的程度。脑电非线性指数监测有可能成为一种观察临床促醒措施疗效的新检测手段。 |
| 关键词：脑电描记术 非线性动力学 意识障碍 |
| Application of EEG nonlinear analysis in monitoring unconsciousness Download Fulltext |
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| Xuanwu Hospital of Capital Medical University, Beijing, 100053;Xuanwu Hospital of Capital Medical University, Beijing, 100053 |
| Fund Project: |
| Abstract: |
| Objective:To investigate the changes of EEG nonlinear properties in unconscious patients and quantify the degree of unconsciousness with EEG nonlinear dynamics analysis. Method:Thirty unconscious patients after severe brain trauma or stroke were involved in the study. All patients′ scores with Glasgow Coma Scale(GCS) were below 8. EEG was recorded in all of them under three states: eyes closed, nociceptive stimulus and auditory stimulus. EEG nonlinear indexes such as correlation dimension (D2), approximate entropy (ApEn) and complexity (Cx) were calculated for all subjects. Result:Under eyes closed state, D2, ApEn and Cx nonlinear indexes kept at low level (Correspondingly, 2.84, 0.53 and 0.26). States under nociceptive stimulus and auditory stimulus had no significant difference compared with eyes closed state. Conclusion:With EEG nonlinear dynamics analysis, the degree of suppression of brain cortex in unconscious patients could be directly measured and real-timely monitored. Monitor of EEG nonlinear indexes might be a new technique that could inspect the clinical efficacy of different awaking methods. |
| Keywords:electroencephalography, nonlinear dynamics, unconsciousness |
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