| 牟 翔,袁 华,李 玲,刘 静,葛雪松,瞿丽莉,陈景藻.高强度次声作用小鼠后海马内P53 mRNA表达的变化[J].中国康复医学杂志,2008,23(4):320~321 |
| 高强度次声作用小鼠后海马内P53 mRNA表达的变化 点此下载全文 |
| 牟 翔 袁 华 李 玲 刘 静 葛雪松 瞿丽莉 陈景藻 |
| 第四军医大学西京医院物理医学与康复科，西安，710032 |
| 基金项目：全军医学科学技术研究“十五”计划指令性课题(OlL071) |
| DOI： |
| 摘要点击次数: 2149 |
| 全文下载次数: 1995 |
| 摘要： |
| 摘要 目的：研究高强度次声作用小鼠后海马内P53mRNA表达的变化。方法：BALB/C小鼠暴露于16Hz 声压130dB次声。每天作用2h，分别作用1、7、14、21和28d后，采用原位杂交的方法观察小鼠海马内P53mRNA表达的改变。结果：130dB次声作用后，海马区域内P53mRNA表达明显增多；在相同声压级强度的次声作用下，随着作用次数的增加，海马内P53mRNA的杂交阳性反应产物增多。结论：一定参数次声作用后，脑内P53mRNA表达的增高，提示脑组织的结构和功能发生变化，导致DNA损伤，神经元受到损害。这一效应与次声的声强和暴露时间有关。P53mRNA在次声导致脑组织损害过程中亦起着非常重要的作用。
关键词 次声；脑损伤；P53mRNA
中图分类号：R332,R49 文献识别码：A 文章编号：1001-1242(2008)-04-0320-02 |
| 关键词：次声 脑损伤 P53mRNA |
| P53 mRNA expression in hippocampus of mice exposed to high intensity infrasound Download Fulltext |
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| Department of Physiotherapy and Rehabilitation, Xijing Hospital, Forth Military Medical University, Xi′an, 710032 |
| Fund Project: |
| Abstract: |
| Objective:To explore the change of P53mRNA in the hippocampus of mice exposed to infrasound of high sound pressure.Method:BALB/C mice were exposed to infrasound of 16Hz 130dB for 2h everyday and lasted for 1, 7, 14, 21 and 28d respectively. In situ hybridization was used to study the expression of P53mRNA in hippocampus. Result: P53mRNA in hippocampus increased after exposed to 130 dB infrasound. Under the same sound pressure level, P53mRNA in hippocampus increased along with the increase of exposure time.Conclusion: Hippocampus is sensitive to infrasound. By effects on P53 mRNA, infrasound may damage the brain. In the meantime, P53 mRNA is an important factor for the brain injury caused by infrasound. The effects related to the sound pressure level and exposure time of infrasound. |
| Keywords:infrasound brain injury P53 mRNA |
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