| 宋景贵,张朝辉,穆俊林,李 冲,顾仁骏.老年性痴呆患者事件相关电位P300和多导睡眠图对照研究[J].中国康复医学杂志,2009,24(2):133~135 |
| 老年性痴呆患者事件相关电位P300和多导睡眠图对照研究 点此下载全文 |
| 宋景贵 张朝辉 穆俊林 李 冲 顾仁骏 |
| 新乡医学院第二附属院,河南省新乡市建设路388号，453002 |
| 基金项目：河南省医学科技创新人才工程项目（2005069） |
| DOI： |
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| 摘要： |
| 目的: 探讨老年性痴呆患者事件相关电位（ERP）和多导睡眠图（PSG）之间的关系。 方法: 对36例临床诊断的老年性痴呆患者及35例年龄匹配的健康人进行对照研究，所有受试者均进行ERP和PSG测试。结果: 研究组中ERP测定的异常率为94.4%（34/36），ERP中N2、P3波潜伏期较对照组延长，P3波幅降低，其差异具有显著性意义（P<0.01），PSG测定睡眠潜伏期延长、觉醒次数和S1阶段增多、总睡眠时间、深睡眠（S3＋S4）、快眼动睡眠时间和睡眠纺锤波指数减少、睡眠效率降低与对照组比较差异有显著性意义（P<0.01）。ERP成分中P3波潜伏期P3波幅与PSG测定中睡眠潜伏期、觉醒次数、总睡眠时间、深睡眠、快眼动睡眠时间、睡眠效率及纺锤波指数等指标存在显著的相关性（P<0.01）。 结论:老年性痴呆患者存在明显的认知功能减退和睡眠质量下降。ERP和PSG可以作为老年性痴呆患者早期诊断的辅助指标。 |
| 关键词：老年性痴呆 认知 睡眠 事件相关电位 多导睡眠图 |
| A comparision of ERP P300 and polysomnogram in patients with senile dementia Download Fulltext |
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| Dept. of Neurology，the Second Affiliated Hospital of Xinxiang Medical College,Xinxiang,453002 |
| Fund Project: |
| Abstract: |
| Objective: To explore the characteristic of event-related potential(ERP) P300 and polysomnogram(PSG) in patients with senile dementia(SD). Method: A total of 36 SD patients and 35 age-matched person(control group) were studied. All the cases were assessed with ERP and PSG, and the results were compared between the two groups. Result: The abnormal rate of ERP in SD patients was 94.4%（34/36）.In SD patients group latency of N2 and P3 of ERP were longer and the amplitude of P3 were lower than those in the controls. There were significant difference between two groups（P<0.01）. Compared with normal controls, in SD patients the sleep latency prolonged; awareness frequency and stageⅠsleep increased; total sleep time, slow-wave sleep(stage Ⅲ-Ⅳ), rapid eye movement(REM), index of sleep spindle and sleep efficacy decreased remarkably(P<0.01). Correlation analysis showed that there was a remarkable correlation in latency and amplitude of P3 of ERP with sleep latency，awareness frequency ，total sleep time，slow-wave sleep，rapid eye movement，sleep efficacy and sleep spindle of PSG in SD patients（P<0.01）. Conclusion: The patients with senile dementia had remembrance cognition degeneration and sleep disorder. It suggested that ERP and PSG test could be served as indexes for early diagnosis of senile dementia. |
| Keywords:senile dementia cognition sleep event-related potential polysomnogram |
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