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金冬梅,庄志强,燕铁斌,向 云,彭 源,郑修元.功能性电刺激治疗对急性脑梗死大鼠运动功能和缺血半影区微管相关蛋白-2表达的影响*[J].中国康复医学杂志,2009,24(6):505~508
功能性电刺激治疗对急性脑梗死大鼠运动功能和缺血半影区微管相关蛋白-2表达的影响*    点此下载全文
金冬梅  庄志强  燕铁斌  向 云  彭 源  郑修元
中山大学附属第二医院康复医学科,广州,510120
基金项目:国家自然科学基金项目(30772304);广东省自然科学基金项目(8451008901000885)
DOI:
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摘要:
      目的:观察功能性电刺激(FES)治疗对急性脑梗死大鼠运动功能和缺血半影区微管相关蛋白-2(MAP-2)表达的影响。方法:制作急性大脑中动脉栓塞模型大鼠。随机分为假手术组、FES安慰治疗组和FES治疗组共三组,每组又分为治疗0d、3d、7d、14d四个亚组,每亚组共6只,术后3天开始FES治疗。FES治疗引起瘫痪侧伸腕伸指动作,每天1次,每次10min。在治疗前和治疗后的各个时间点采用网屏试验评定运动功能,评定后取材,应用免疫组化技术观察半影区MAP-2变化。结果:治疗7d和14d后,FES治疗组的运动功能
关键词:功能性电刺激  脑梗死  运动功能  微管相关蛋白
Effects of functional electrical stimulation on motor function and protein expression of microtube-associated protein 2 in the penumbra field of the rats with acute cerebral infarction    Download Fulltext
Department of Rehabilitation Medicine, the Second Affiliated Hospital, Sun-Yat Sen University, Guangzhou,510120
Fund Project:
Abstract:
      Objective: To observe the effects of functional electrical stimulation (FES) on motor function and the expression of microtube-associated protein 2 (MAP-2) in the penumbra field of the rats with acute cerebral infarction. Method:Acute cerebral infarction was made by means of middle cerebral artery occlusion. Rats were randomly divided into sham-operated, FES placebo-treatment and FES treatment groups. Each group was divided into 0-day, 3-day, 7-day and 14-day subgroups and 6 rats for each subgroup. FES treatment to induce wrist and fingers extension was carried out 3 days after operation and was performed once daily, 10 minutes each time. The motor function and protein expression of MAP-2 were observed before treatment and at each treatment points. Result:After treatment for 7 days and 14 days, the motor function of FES treatment group was significantly improved, comparing with that of FES sham-treatment group (P<0.05), and the MAP-2 labeled cells and expression were also significantly enhanced comparing with that of the FES sham-treatment group (P<0.01). Conclusion:FES treatment can improve motor function and enhance the expression of MAP-2 in the penumbra field of the rats with acute cerebral infarction.
Keywords:functional electrical stimulation  cerebral infarction  motor function  microtube-associated protein
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