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何建成,王振华,袁灿兴,庄燕鸿.复方地黄方对帕金森病大鼠神经行为学及氧化应激的影响[J].中国康复医学杂志,2009,24(7):590~592
复方地黄方对帕金森病大鼠神经行为学及氧化应激的影响    点此下载全文
何建成  王振华  袁灿兴  庄燕鸿
上海中医药大学基础医学院,上海,201203
基金项目:国家自然基金(30672684);上海市教委(05CZ04);上海市重点学科(第三期)(S30302)
DOI:
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摘要:
      目的:观察复方地黄方对帕金森病(PD)大鼠神经行为学及氧化应激的影响。方法:采用6-羟基多巴胺(6-OHDA)注射于脑右侧黑质造成偏侧PD模型。模型组用复方地黄方(4.14g/ml,2ml/d)中药进行治疗,此外设立了正常对照组、假手术组。观察PD大鼠神经行为学、氧化应激的变化及复方地黄方的作用。结果:PD模型组进行复方地黄方治疗后有明显的神经行为学改变,谷胱甘肽过氧化物酶(GSH-Px)、谷胱甘肽(GSH)、超氧化物歧化酶(SOD)含量均明显降低,活性氧与丙二醛(MDA)含量升高。结论:复方地黄方能明显改善PD模型大鼠的旋转行为,提高其抗氧化能力和清除自由基的能力。
关键词:帕金森病  复方地黄方  神经行为学  氧化应激
Effects of compound rehmannia prescription on the neuroethology and oxidative stress in rats with Parkinson′s disease    Download Fulltext
Shanghai University of Traditional Chinese Medicine, Shanghai,201203
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Abstract:
      Objective:To observe the effects of compound rehmannia prescription on neuroethology and oxidative stress in rats with Parkinson′s disease(PD). Method:Model of hemilateral PD rat was established with injection of 6-hydroxydopamine(6-OHDA) into the substantia nigra of right side brain. The rats in PD model group were treated with compound rehmannia prescription(4.14g/ml,2ml/d);in addition, a normal control group and a sham-operated group were established. The changes of neuroethology and oxidative stress in PD rats after treatment with compound rehmannia prescription were observed. Result:The rats in PD model group after treatment with compound rehmannia appeared obvious changes of neuroethology,the contents of glutathione-peroxidase(GSH-Px),glutathione(GSH),superoxide dismutase(SOD) reduced significantly, and the contents of reactive oxygen species(ROS) and malondialdehyde(MDA) elevated significantly.Conclusion:Compound rehmannia prescription can significantly improve the spinning behavior of PD model rats,and elevate it′s antioxidant ability and scavenging free radicals ability.
Keywords:Parkinson′s disease  compound rehmannia prescription  neuroethology  oxidative stress
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