| 刘 静,薄 海,李雪华,刘亚敏,张红英.低氧联合运动对大鼠肺血管重构的保护作用及结缔组织生长因子表达的影响[J].中国康复医学杂志,2009,24(7):593~596 |
| 低氧联合运动对大鼠肺血管重构的保护作用及结缔组织生长因子表达的影响 点此下载全文 |
| 刘 静 薄 海 李雪华 刘亚敏 张红英 |
| 武警医学院病理学教研室，天津，300162 |
| 基金项目：武警医学院科研基金项目（WY200810）与武警总医院科研基金资助项目(WZ2008035)共同资助 |
| DOI： |
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| 摘要： |
| 目的：探讨低氧与运动联合应用对大鼠肺血管重构及结缔组织生长因子(CTGF)表达的影响，揭示低氧/缺氧适应机制。方法：30只雄性SD大鼠随机分为常氧对照组(C组)、低氧组(H组)和低氧与运动联合组(H+E组)。H组与(H+E)组置于模拟海拔3000m，8h/d, 6d/周, 5周；(H+E)组辅以低负荷跑台训练，5°，15m/min，1h/d。测量肺动脉平均压(mPAP)、血管（WT）%、（WA）%，RT-PCR检测CTGF mRNA表达变化情况。结果：H组与（H+E）组大鼠mPAP、WT%、WA%及CTGF mRNA均较C组明显升高(P<0.05)；(H+E)组大鼠上述指标则显著低于H组(P<0.05)。结论：低氧与运动联合应用降低CTGF表达可能是减轻肺血管重构的重要原因，CTGF可能与低氧/缺氧适应密切相关。 |
| 关键词：低氧与运动联合应用 低氧性肺动脉高压 肺血管重构 结缔组织生长因子 |
| Effects of hypoxia-exercises on pulmonary vascular structural remodeling and expressions of CTGF in rats Download Fulltext |
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| Department of Pathology, Medical College of Chinese People′s Armed Polic Forces, Tianjin, 300162 |
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| Abstract: |
| Objective: To investigate the effects of hypoxia-exercises on pulmonary vascular structural remodeling and expressions of connective tissue growth factor(CTGF). Method: Thirty male SD rats were divided into control group, hypoxia group and hypoxia-exercises group. The (mPAP), (WT)% and (WA)% were measured. The expressions of CTGF mRNA in pulmonary arteries were evaluated by reverse transcriptase-polymerase chain reaction (RT-PCR) technique. Result: The mPAP, WT%, WA%, and CTGF mRNA level in hypoxia group and hypoxia-exercises group were significantly higher than those in control group(P<0.05), while those in hypoxia-exercises group were significomtly lower than those in hypoxia group(P<0.05). Conclusion: After hypoxia-exercises CTGF mRNA level reduced, which may result in ameliorating pulmonary vascular structural remodeling. CTGF may play an important protective role in the mechanism of hypoxic altitude acclimation of pulmonary tissue. |
| Keywords:hypoxia-exercises hypoxic pulmonary artery hypertension pulmonary vascular structural remodeling connective tissue growth factor |
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