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谢 敏,徐 波,王泽军.游泳训练对大鼠空间学习记忆能力与海马、前额叶皮质环磷酸腺苷、环磷酸鸟苷水平的影响[J].中国康复医学杂志,2009,24(11):1002~1005
游泳训练对大鼠空间学习记忆能力与海马、前额叶皮质环磷酸腺苷、环磷酸鸟苷水平的影响    点此下载全文
谢 敏  徐 波  王泽军
上海工程技术大学体育部,上海 201620;
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DOI:
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摘要:
      目的:探讨8周游泳训练对大鼠空间学习记忆能力的影响与环磷酸腺苷(cAMP)、环磷酸鸟苷(cGMP)信号传导途径的关系。方法:以大鼠为实验对象,采用Morris水迷宫法,研究8周游泳训练对大鼠空间学习记忆能力的作用;采用放射免疫法测定研究8周游泳训练对大鼠海马、前额叶皮质中cGMP、cAMP含量的影响。结果:①Morris水迷宫的测试表明,8周游泳训练后,大鼠的空间记忆能力有一定提高。②与安静组相比,8周游泳训练使大鼠海马cAMP水平非常显著性增加(P<0.01),cAMP/cGMP比值显著性增高(P<0.05),同时,前额叶皮质cAMP与cAMP/cGMP比值显著性增高(P<0.05)。结论:8周的游泳训练在提高大鼠空间学习记忆能力的同时伴有海马、前额叶皮质cAMP含量与cAMP/cGMP比值的变化,从而部分揭示了运动促进学习记忆能力提高的可能机制。
关键词:运动  大鼠  学习  记忆  海马  前额叶皮质  环磷酸鸟苷  环磷酸腺苷
Effect of swimming training on spatial learning-memory function of rats and its relationship with cAMP and cGMP in hippocampus and prefrontal cortex    Download Fulltext
Dept. of Physical Education, Shanghai University of Engineering Science, Shanghai,201620
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Abstract:
      Objective: To analyze the influence of long-term swimming training on spatial learning-memory in rats and its relationship with cyclic adenosine monophosphate(cAMP) and cyclic guanosine monophosphate(cGMP) signal transduction pathway. Method: After 3 times adaptable swimming exercises(30min each time), 40 male SD rats were divided into 2 groups: control group (CR, n=20) and exercises, group (TR, n=20). CR group didn′t swim, and TR group swam without burden(6 times/week,60 min each time). After 8 weeks training, 10 rats were selected from both groups respectively for examing of Morris water maze test. Radioimmunoassay was used to measure the levels of cAMP and cGMP in hippocampus and prefrontal cortex of rats. Result: ①Compared with CR group, in TR group learning-memory improved in a certain extent:②Compared with CR group, in TR group, the level of cAMP in hippocampus enhanced very obviously(P<0.01), the cAMP/cGMP ratio enhanced obviously(P<0.05); in prefrontal cortex the levels of cAMP and cAMP/cGMP ratio enhanced obviously(P<0.05). Conclusion: Swimming training for 8 weeks improved the spatial learning-memory of rats in a certain extent, and elevated the level of cAMP and cAMP/cGMP ratio in hippocampus and prefrontal cortex of rats obviously. It is suggested that exercises might affect learning-memory by cAMP and cGMP signal transduction pathway.
Keywords:exercises  rats  learning  memory  hippocampus  prefrontal cortex  cyclic guanosine monophosphate  cyclic adenosine monophosphate
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