| 赖红梅,陈彩珍,蒋慧萍.有氧运动训练对老年大鼠线粒体DNA含量、呼吸链复合酶活性的影响[J].中国康复医学杂志,2009,24(12):1109~1111 |
| 有氧运动训练对老年大鼠线粒体DNA含量、呼吸链复合酶活性的影响 点此下载全文 |
| 赖红梅 陈彩珍 蒋慧萍 |
| 华东政法大学刑事司法学院，上海，200042 |
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| DOI： |
| 摘要点击次数: 2844 |
| 全文下载次数: 1899 |
| 摘要： |
| 目的：研究长时间有氧运动训练对老年大鼠心肌、脑组织线粒体DNA含量及线粒体呼吸链酶复合体的影响。 方法：将大鼠随机分为3组：青年组、老年对照组、老年运动训练组，运动组大鼠在水中进行90d渐进游泳训练，测定心脏、脑组织线粒体DNA含量、线粒体复合体Ⅰ、 Ⅳ的活性。结果：①与青年组相比老年对照组心肌线粒体DNA含量升高（P<0.01）、线粒体复合体Ⅰ、Ⅳ活性明显降低（P<0.05—0.01），脑组织线粒体DNA含量升高（P<0.01）、线粒体复合体Ⅰ、Ⅳ活性明显降低（P<0.05—0.01）。②与老年对照组相比老年运动训练组心肌线粒体DNA含量明显降低（P<0.05）、线粒体复合体Ⅰ、Ⅳ活性明显升高（P<0.05—0.01），脑线粒体DNA含量没有显著变化（P>0.05）、线粒体复合体Ⅰ、Ⅳ活性明显升高（P<0.05—0.01）。结论：长时间有氧运动训练可以降低老年大鼠心肌线粒体DNA含量，增加线粒体呼吸链复合酶活性，延缓衰老过程中线粒体功能的退行性变化。 |
| 关键词：老年 线粒体DNA含量 有氧运动 |
| The long time aerobic training effect on the mitochondrial DNA content and the activity of mitochondrial respiratory chain complexes in aging rats Download Fulltext |
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| East China University of Political Science and Law, Shanghai, 200042 |
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| Abstract: |
| Objective: To study long time aerobic training effect on mitochondrial DNA (mtDNA) content and activities of mitochondrial respiratory chain complexes in the myocardium and brain tissues of aged rats. Method: Forty-five rats were randomly divided into three groups Group A(n=15)younger rats did not received training; Group B(n=15) old rats did not received training; Group C(n=15) old rats received gradually training for 90 days. the mtDNA content were determined by methods of Yan etc, the activity of mitochondrial respiratory chain complexes in myocardium and brain tissues were determined by methods of Wu etc. Result: The mitochondrial DNA content in myocardium and brain tissues significantly increased(P<0.01) and the activity of mitochondrial respiratory chain complexes in myocardium and brain tissues significantly decreased (P<0.05—0.01) in the aging control group as compared with those in the young group. The mitochondrial DNA content in myocardium significantly decreased(P<0.05), while there was no significant difference in brain. The activity of mitochondrial respiratory chain complexes in myocardium and brain tissues significantly increased(P<0.05—0.01) in the aging training group as compared with those in the aging control group. Conclusion: the long time aerobic training could decline the mitochondrial DNA content and increase the activity of mitochondrial respiratory chain complexes in myocardium and brain tissues in aging rats. |
| Keywords:aging the content of mitochondrial DNA aerobic training |
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