| 周谋望,王文婷,黄红拾,陈亚平,杨延砚,朱根应.脊神经后根对大鼠排尿和勃起功能的选择性传导机制研究[J].中国康复医学杂志,2010,25(5):393~397 |
| 脊神经后根对大鼠排尿和勃起功能的选择性传导机制研究 点此下载全文 |
| 周谋望 王文婷 黄红拾 陈亚平 杨延砚 朱根应 |
| 北京大学第三附属医院康复医学科，100083 |
| 基金项目：国家自然科学基金资助项目(30672096) |
| DOI： |
| 摘要点击次数: 2186 |
| 全文下载次数: 1941 |
| 摘要： |
| 摘要
目的：探讨脊神经后根神经小束对SD大鼠排尿和勃起功能的选择性传导机制。
方法：成年雄性SD大鼠40只，10只用逆行神经示踪技术确定SD大鼠排尿和勃起功能的脊髓中枢，并对其腰骶部脊神经后根进行显微解剖学研究；30只进行电生理学研究：分别对大鼠排尿及勃起反射中枢所在脊髓节段的脊神经后根神经小束进行电刺激，同时记录膀胱内压、尿道灌注压和阴茎海绵体内压的变化情况，观察各神经小束对膀胱逼尿肌、尿道外括约肌和阴茎海绵体的选择性传导作用。
结果：SD大鼠排尿和勃起功能的低级中枢主要位于L6、S1脊髓节段。后根分束可达神经小束水平，电刺激L6、S1脊神经后根某些小束时，膀胱内压上升，但尿道灌注压和阴茎海绵体内压的变化幅度不大；电刺激其他一些小束时，尿道灌注压上升，但膀胱内压和阴茎海绵体内压在刺激前后的变化不大；或是阴茎海绵体内压急剧上升，但膀胱内压和尿道灌注压在刺激前后的变化不大；或是引起上述两个或三个压力的同时改变。
结论：SD大鼠L6、S1脊神经后根不同小束对膀胱逼尿肌、尿道外括约肌和阴茎海绵体的传导效能存在差异；通过显微解剖及电刺激可以区别L6、S1中主要传导膀胱逼尿肌、尿道外括约肌及阴茎海绵体的不同的后根神经小束。 |
| 关键词：脊神经后根 排尿 勃起 选择性传导 大鼠 |
| Selective innervation of spinal nerve posterior rootlets for micturition and erection function in rats Download Fulltext |
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| Dept. of Rehabilitation Medicine, Peking University Third Hospital, Beijing, 100191, China |
| Fund Project: |
| Abstract: |
| Abstract
Objective: To investigate the selective innervation of spinal nerve posterior rootlets for micturition and erection function in rats.
Method: Forty male SD rats of clean grades, aged 6 weeks, were selected. Ten rats were conducted in retrograde nerve tract tracing study and microsurgical anatomy research. Thirty rats were chosen for electro-physiology research. The L6 and S1 posterior rootlets of anesthetic rats were applied electrostimulation respectively, the intravesical pressure, urethral perfusion pressure and intracavernous pressure were recorded simultaneously, and innervation effects were analyzed.
Result: CB-HRP labeled neurons were observed in L6 and S1 spinal cord segments. The posterior root were divided into 3-10 rootlets. When some posterior rootlets of L6 and S1 were applied with electrostimulation, intracavernous pressure rose obviously, but intravesical pressure and urethral perfusion pressure curve didn′t show great change. When other rootlets were stimulated, the difference between max intravesical pressure and basic pressure could reach 45.17 cmH2O, but urethral perfusion pressure and intracavernous pressure didn′t show great change. When others were stimulated, the difference between max urethral perfusion pressure and basic pressure could be 39.87 cmH2O maximally, but there was no great change in intravesical pressure and intracavernous pressure. Also there were some other rootlets which could induce 2 or 3 kinds of pressure mentioned above changing simultaneously.
Conclusion: The conductions of L6 and S1 posterior rootlets of rats′ bladder detrusor, external urethral sphincter and penis cavernous are significantly distinct, different rootlets can be distinguished by microanatomy and electrostimulation. |
| Keywords:spinal nerve posterior rootlet micturition erection selective conduction rat |
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