| 叶添文,贾连顺,严望军,周许辉,叶晓健,倪 斌,袁 文.糖尿病大鼠脊髓损伤后神经行为学和组织病理学研究[J].中国康复医学杂志,2010,25(6):497~500 |
| 糖尿病大鼠脊髓损伤后神经行为学和组织病理学研究 点此下载全文 |
| 叶添文 贾连顺 严望军 周许辉 叶晓健 倪 斌 袁 文 |
| 上海第二军医大学附属长征医院骨科，200003 |
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| DOI： |
| 摘要点击次数: 2159 |
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| 摘要
目的：了解糖尿病大鼠脊髓损伤（SCI）后神经功能恢复的情况。
方法：将SD大鼠随机分成假手术对照组、假手术糖尿病组、SCI对照组和SCI糖尿病组。一次性腹腔注射链脲佐菌素建立糖尿病模型，Allen法制作SCI模型。在伤后10d内每天对各实验组大鼠进行斜板试验评价神经功能，并于伤后第1天和第10天观察大鼠脊髓组织形态学变化。
结果：SCI糖尿病组大鼠伤后斜板试验临界角度明显低于SCI对照组，差异有显著性意义。组织病理学显示SCI糖尿病组大鼠脊髓组织灰质和白质严重受损，神经细胞稀少、尼氏体消失。
结论：糖尿病大鼠脊髓容易遭受自由基损害，导致SCI后神经功能恢复不佳。 |
| 关键词：糖尿病 脊髓损伤 神经行为学 组织病理学 |
| The experimental study of neurobehavior and histopathology in diabetic rats following spinal cord injury Download Fulltext |
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| Dept. of Orthopaedics Surgery,Shanghai Changzheng Hospital, Second Military Medical University,Shanghai, 200003 |
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| Abstract: |
| Abstract
Objective: To study the neurological recovery in diabetic rats following spinal cord injury(SCI).
Method： Experimental diabetes was produced by once intraperitoneal injection of streptozotocin in adult male SD rats. SCI animal model was made by Allen′s method. The rats were divided into sham-control group, sham-diabetic group, SCI-control group, SCI-diabetic group randomly. Postinjury neurological function in every experimental rat was assessed using inclined plane test daily for 10 d. Pathological changes in spinal cord were studied at the 1st d and 10th d post trauma.
Result: The critical angle of inclined plane test in diabetic rats was significantly lower as compared to that in control rats following SCI. Histopathological changes were more significant in diabetic rats than that in control rats following SCI.
Conclusion: It was suggested that diabetic animals were more susceptible to free radicals and resulted in poor recovery of neurological function following SCI. |
| Keywords:diabetes spinal cord injury neurobehavior histopathology |
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