李海英,赵 娟,佟长青,薄 海.间歇性低氧及游泳运动对大鼠右心室线粒体超微结构的影响[J].中国康复医学杂志,2010,25(7):643~645 |
间歇性低氧及游泳运动对大鼠右心室线粒体超微结构的影响 点此下载全文 |
李海英 赵 娟 佟长青 薄 海 |
武警医学院生理学与病理生理学教研室,天津,300162 |
基金项目:武警医学院科研立项课题项目(WY2007-3) |
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摘要
目的:观察间歇性低氧及游泳运动对大鼠右心室线粒体超微结构的影响,为高原医学的研究提供实验资料。
方法:Wistar大鼠随机分为常氧对照组、低氧对照组和低氧运动组。用MPA-心功能分析系统记录血压和心率。用透射电镜观察右心室线粒体超微结构。
结果:低氧对照组:大鼠肌原纤维间大量增生线粒体挤压变形,线粒体嵴和基质明显增多,线粒体间见大量空泡。线粒体排列无序,线粒体凝集变形。低氧运动组:肌膜下线粒体较多,线粒体排列有序。高倍镜下可见线粒体基质增多。结论:低氧对大鼠右心室线粒体的超微结构有一定的损伤,低氧及游泳运动对大鼠右心室线粒体超微结构有明显改善。 |
关键词:间歇性低氧 运动 线粒体 大鼠 |
Influence on mitochondria ultrastructure of right ventricle during intermittent hypoxia and swimming exercise in rats Download Fulltext |
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Department of Physiology and Pathophysiology, Medical College of the Chinese People′s Armed Police Forces, Tianjin, 300162 |
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Abstract: |
Abstract
Objective: To observe the mitochondria ultrastructure of right ventricle during intermittent hypoxia and swimming exercise in rats to offer experimental data in plateau iatrical research.
Method: Wistar rats were randomly divided into the normoxia control group, the hypoxia control group and the hypoxia training group. Blood pressure and heart rate were recorded by MPA-heart function analytical system. Mitochondria ultrastructure of right ventricle was observed by transmission electron microscope.
Result: The hypoxia control group: Mitochondria hyperplasia, extruded deformation, mitochondrial crista and matrix increasing obviously and a great quantity vacuoles among mitochondria were found. Disarrangement and agglutinative deformation of mitochondria were also observed. The hypoxia training group: Mitochondria increasing under sarcolemma and arranging regularly were found. Mitochondrial matrix increasing could be observed under high power lens.
Conclusion: The mitochondria ultrastructure of right ventricle was damaged during hypoxia, and the mitochondria ultrastructure of right ventricle improved significantly during intermittent hypoxia and swimming exercise. |
Keywords:intermittent hypoxia exercise mitochondria rat |
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