| 王福文,赵敬国,王纯雨,胡志力,李 杰.反复力竭性运动后不同时相大鼠心电图的动态改变[J].中国康复医学杂志,2010,25(11):1030~1034 |
| 反复力竭性运动后不同时相大鼠心电图的动态改变 点此下载全文 |
| 王福文 赵敬国 王纯雨 胡志力 李 杰 |
| 山东省医学科学院药物研究所，山东省现代医用药物与技术重点实验室，济南，250062 |
| 基金项目：山东省自然科学基金项目（ZR2009CM089），山东省教育厅科技计划项目（J07YE09） |
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| 摘要： |
| 摘要
目的：观察大鼠反复力竭性游泳运动前、后不同时相心电图（ECG）的动态改变，以评价运动性心肌损伤的变化规律。
方法：采用经典的Thomas的方法通过力竭性游泳运动建立运动性心肌损伤实验动物模型。ECG检测采用DSI植入式心电信号遥测系统。健康无训练的Wistar雄性大鼠24只，尾部负体重2% 的负荷，每天游泳运动至力竭状态（一次游泳时间不小于3h），连续1周（7天）。分别于运动前和末次力竭性游泳运动结束后即刻、1h、3h、6h、12h、24h、48h和96h不同时相记录ECG。
结果：经1周反复力竭性游泳运动后，大鼠心电图主要发生了两种心肌缺血损伤性ST-T改变（发生率为100%）。①运动后即刻大鼠心电图ST段明显抬高和T波高耸；6h—12h 基本恢复；24h—48h ST段又有明显抬高，T波幅度升高、高耸；96h ST段有所下移、T波幅度恢复但变窄（发生率为79.17%）。②运动后即刻心电图T波明显低平；运动后3h—6h ST段有所下移，T波逐渐恢复；12h—24h ST段恢复，T波双峰、变宽、高耸；48h ST段显著下移，T波再次低平，随后动物发生死亡（发生率为20.83%）。心律不齐发生率为45.83%。
结论：反复力竭性运动后不同恢复期，大鼠心电图呈现两次周期性损伤性ST-T改变，说明大鼠心肌存在有早期和延迟性的损伤性改变，运动心电图对运动性心肌损伤具有重要的诊断意义，为临床诊断和康复治疗提供理论依据。 |
| 关键词：力竭性运动 心肌损伤 心电图 DSI遥测系统 大鼠 |
| The dynamic changes on ECG in different time cases after repeated exhausted exercise in rats Download Fulltext |
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| Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, 250062 |
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| Abstract: |
| Abstract
Objective：To study the dynamic changes on electrocardiograms (ECG) in different time periods after repeated exhausted exercise in rats,in order to evaluate the changing rule of exercise-induced myocardial damage.
Method：The animal models of exercise-induced myocardial injury were established according to Thomas′s method. Healthy untrained 24 male Wistar rats,with 2% bodyweight attached to each tail,were forced to swim until exhaustive (swimming time exceeded 3 hours daily) for 1 week. ECG (leadⅡ) was recorded and analyzed with DSI cardio-vascular radiotelemetry system at before exercise and immediately,1,3,6,12,24,48 and 96 hours after exhausted exercise in rats.
Result：After 1-week consecutive daily exhausted swimming,the two kinds of ST-T change patterns on ECG were observed as follows in rats(100%):①Compared with pre-exercise,the ECGs revealed ST segment elevating significantly and great risen T waves at immediately after exhausted exercise, and near to normal level 6 hours later, then ST segment re-elevation with high and sharp T wave at 24,48 hours and ST segment depression with narrow T wave at 96 hours post-exercise(79.17%).②The ECGs in rats showed obviously T wave flat at immediately post-exercise, ST segment depression with T wave recovering gradually at 3,6 hours post-exercise,then ST segment recovering with wide and soaring double-peak T wave at 12,24 hours later,and significant ST segment depression associated with T wave flat at 48 hours post-exercise, finally the rats died (20.83%).The arrhythmia takes place(45.83%).
Conclusion：The ECGs of rats revealed two cyclic ST-T changes in different phases after exhausted exercise. The results suggest that there are early myocardial injury and delayed-onset myocardial injury in rats, Athletic electrocardiogram have an important diagnosis value on myocardial injury induced-exercise. |
| Keywords:exhausted exercise myocardial injury electrocardiogram DSI radiotelemetry system rat |
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