| 曾凡硕,周谋望,刘 楠,杨延砚,李芮志.犬脊髓损伤痉挛性膀胱动物模型的建立及尿动力学分析[J].中国康复医学杂志,2011,26(11):1000~1003 |
| 犬脊髓损伤痉挛性膀胱动物模型的建立及尿动力学分析 点此下载全文 |
| 曾凡硕 周谋望 刘 楠 杨延砚 李芮志 |
| 北京大学第三医院康复医学科，100191 |
| 基金项目：国家自然科学基金资助项目(30672096) |
| DOI： |
| 摘要点击次数: 2203 |
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| 摘要： |
| 摘要
目的:探讨犬脊髓损伤后痉挛性膀胱模型的建立。
方法：12只成熟雄性比格犬，在T10水平硬膜外夹闭脊髓，制作脊髓损伤模型。用尿动力学检测分析造模术前及术后每周的最大膀胱容量、膀胱压力、膀胱顺应性和尿道压力，直到模型成功。
结果：12只犬死亡2只，其余10只造模成功，造模成功时尿动力学指标如下：与术前相比最大膀胱容量减少,膀胱顺应性下降,膀胱压力上升，其差异均有显著性意义(P<0.05)；尿道压力与术前相比无显著性差异(P>0.05)。造模成功时间为2—5周，其中5只为2周，1只为3周，2只为4周，2只为5周。
结论：犬痉挛性膀胱模型符合骶上脊髓损伤后的膀胱表现，适用于痉挛性膀胱的研究。 |
| 关键词：脊髓损伤 痉挛性膀胱 动物模型 犬 尿动力学 |
| The canine model of spastic bladder after spinal cord injury and its urodynamic evaluation Download Fulltext |
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| Dept. of Rehabilitation Medicine, Peking University Third Hospital, 100191 |
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| Abstract: |
| Abstract
Objective: To establish a canine model of spastic bladder after spinal cord injury.
Method: Twelve mature male beagle dogs were selected. The spinal cord were transected epidurally at T10 level. After that，the urodynamic studies were performed in every dog before operation and every week postoperation until the spastic bladder models were successful. The evaluation parameters included maximum cystometric capacity, intravesical pressure ,bladder compliance and urethral pressure.
Result: In 10 of 12 dogs spastic bladders, were found but 2 dogs died. When spastic bladder model was established successfully, the urodynamic indenes were as follows: Compared with preopertation, the maximum cystometric capacity and bladder compliance decreased significantly(P<0.05), while the intravesical pressure increased significantly(P<0.05). But the urethral pressure had no significant difference (P>0.05). The time to form the model needed approximately 2—5 weeks. In detail, 5 dogs were formed the spastic blodder model in 2 weeks, 1 in 3 weeks, 2 in 4 weeks, and 2 in 5 weeks.
Conclusion:The canine spastic bladder models showed the same features both clinically and urodynamically as those in spastic bladder after above sacro-level spinal cord injury. It could be used as the model in research of spastic bladder after spinal cord injury. |
| Keywords:spinal cord injury spastic bladder animal model canine urodynamics |
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