| 杨慎峭,金荣疆,朱天民,马红彦,冯丽娟,毛雪莲.康复训练结合电针对脑卒中肢体痉挛大鼠γ-氨基丁酸能中间神经元表达的影响[J].中国康复医学杂志,2013,28(3):198~203 |
| 康复训练结合电针对脑卒中肢体痉挛大鼠γ-氨基丁酸能中间神经元表达的影响 点此下载全文 |
| 杨慎峭 金荣疆 朱天民 马红彦 冯丽娟 毛雪莲 |
| 成都中医药大学针灸推拿学院康复教研室，四川成都十二桥路37号， 610075 |
| 基金项目：国家自然科学基金资助项目（81273852） |
| DOI： |
| 摘要点击次数: 2106 |
| 全文下载次数: 2562 |
| 摘要： |
| 摘要
目的：观察康复训练、电针、康复训练结合电针治疗方案对脑卒中肢体痉挛大鼠神经功能、肌张力及脑干、脊髓颈、腰膨大部位γ-氨基丁酸(GABA)能中间神经元钙结合蛋白-D28K(CB)、微白蛋白(PV)表达的影响。
方法：75只SD大鼠随机分为5组，其中模型组、康复组、电针组和综合组采用线栓法建立局灶性脑缺血动物模型，空白组不做任何处理。康复组、电针组、综合组每天治疗1次，每次30min，连续治疗6d后，检测各组肌张力、神经功能缺损，以及PV、CB的表达情况。
结果：6d治疗后，与模型组比较，康复组、电针组和综合组神经功能缺损评分值均显著降低（P<0.05），以综合组最为明显，组间比较有显著性意义（P<0.05）；肌张力均有所降低（P<0.05），以综合组最为明显，组间比较有显著性意义（P<0.05）；大鼠脑干、脊髓颈膨大、腰膨大中CB和PV积分光密度值均上升，差异有显著性意义（P<0.05），以综合组增多最为明显，组间比较差异有显著性意义（P<0.05）。
结论：康复训练、电针、康复训练结合电针三种不同的治疗方案，均可改善脑卒中肢体痉挛大鼠的神经功能、肌张力，并可上调脑干、脊髓颈膨大、腰膨大中CB、PV的表达，而尤以康复训练结合电针治疗方案效果更好。 |
| 关键词：γ-氨基丁酸 中间神经元 脑卒中 痉挛 康复训练 电针 |
| Experimental research on effects of rehabilitation training combined with electro-acupuncture treatment on expression of interneurons with γ-aminobutyric acid energy in stroke rats with limb spasticity Download Fulltext |
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| Department of Acupuncture and Massage, Chengdu University of Traditional Chinese Medicine, Chengdu China，610075 |
| Fund Project: |
| Abstract: |
| Abstract
Objective：To observe effects of rehabilitation training, electro-acupuncture and rehabilitation training combined with electro-acupuncture treatment on neural function，muscle tension，and expressions of calbindin-D28k (CB) and parvalbumin（PV） in interneurons with γ-aminobutyric acid（GABA） energy in brain stem, cervical and lumbar intumenssence of spinal cord of stroke rats with limb spasticity.
Method: A total of 75 SD rats were randomly divided into five groups. Model group, rehabilitation training group, electro-acupuncture group and rehabilitation training combined with electro-acupuncture treatment group were established focal cerebral ischemic animal models using the suture method; blank group hadn't any treatment. Each treatment group was treated once a day. Six days later, the neural function, muscle tension and PV as well as CB expressions were detected.
Result: After 6-day treatment, in rehabilitation group, electro-acupuncture group and combined group neurological deficits scores were significantly lower than that in model group(P<0.05), the combined group was most obviously, comparison between groups showed statistically significance (P<0.05). Muscle tension of each treatment group weas lower(P<0.05), in combined group that was most obviously, comparison between groups showed statistically significance (P<0.05). In brain stem, cervical and lumbar intumescence of spinal cord of rats of each treatment group, CB and PV integrated optical density rose (P<0.05), in combined group integrated optical density increased most obviously, comparison between groups showed statistically significance (P<0.05).
Conclusion: Rehabilitation training,electro-acupuncture and rehabilitation training combined with electro-acupuncture all could improve nerve function, muscle tension, and raise the expressions of CB and PV in stroke rats with limb spasticity. The effects of rehabilitation training combined with electro-acupuncture was the best. |
| Keywords:γ-aminobutyric acid interneuron stroke spasticity rehabilitation training electro-acupuncture |
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