| 王 赛,邹恩苗,林海燕,屠文展,李江茹,程 博,蒋松鹤.夹脊、督脉电针对大鼠脊髓损伤前炎性细胞因子表达的影响[J].中国康复医学杂志,2013,28(5):389~392 |
| 夹脊、督脉电针对大鼠脊髓损伤前炎性细胞因子表达的影响 点此下载全文 |
| 王 赛 邹恩苗 林海燕 屠文展 李江茹 程 博 蒋松鹤 |
| 温州医学院附属第二医院康复科，325027 |
| 基金项目：温州市科技局资助项目（Y20110069） |
| DOI： |
| 摘要点击次数: 2070 |
| 全文下载次数: 2155 |
| 摘要： |
| 摘要
目的：观察夹脊、督脉不同配穴的电针对脊髓损伤（SCI）后的大鼠前炎性细胞因子表达的影响。
方法：SD大鼠32只随机分为4组：假模组（n=8）、模型对照组（n=8）、夹脊电针组（n=8）、督脉电针组（n=8）。夹脊电针组、督脉电针组于SCI后0.5h和4h分别在夹脊与督脉的穴位进行1次电针治疗。SCI后8h，每组8只大鼠行Western-blot检测脊髓IL-1β、IL-6、TNF-α蛋白含量的表达。
结果：假模组、夹脊电针组、督脉电针组IL-lβ、IL-6、TNF-α的蛋白含量均低于模型对照组，差异有显著性意义（P<0.05）。夹脊电针组、督脉电针组之间差异无显著性意义（P>0.05）。
结论：夹脊、督脉电针可以通过抑制SCI后IL-lβ、IL-6、TNF-α3种前炎性细胞因子的表达，抑制SCI急性期的炎症反应来保护脊髓，减轻损伤的发生，起到神经保护作用。 |
| 关键词：脊髓损伤 电针治疗 夹脊 督脉 神经保护 |
| Impaction of Jiaji and Du Meridian electroacupuncture treatment on expressions of pro-inflammatory cytokines in spinal cord injury of rats Download Fulltext |
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| Dept. of Rehabilitation Medicine, The Second Hospital of Wenzhou Medical College, 325027 |
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| Abstract: |
| Abstract
Objective: To observe the expressions of pro-inflammatory cytokines of spinal cord injury（SCI） rats undertaking electroacupuncture treatment（EA） at Jiaji and Du Meridian.
Method: Thirty-two SD rats were randomly divided into four groups: sham module group(n=8), control module group (n=8), Jiaji EA group (n=8), Du Meridian EA group (n=8). Jiaji EA group and Du Meridian EA group were treated with EA treatment at points of Jiaji and Du Meridian 0.5h and 4h after SCI, respectively. 8h after SCI, Western-blot was used to detect the expressions of IL-1β, IL-6 and TNF-α protein in SCI section.
Result: Compared with control module group, the expressions of IL-1β, IL-6 and TNF-α proteins SCI sections were significantly lower than those in the sham module group， Jiaji EA group, and Du Meridian EA group(P<0.05). No significant difference was detected between Jiaji EA group and Du Meridian EA group(P>0.05).
Conclusion: Jiaji and Du Meridian EA could inhibit high expressions of IL-1β, IL-6 and TNF-α after SCI, inhibit inflammatory response in acute phase of SCI to protect the spinal cord, reduce the occurrence of injury, to play neuroprotective effect. |
| Keywords:spinal cord injury electroacupuncture Jiaji Du Meridian neuroprotective effect |
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