| 祁冬晴,江钟立,林 枫,吴 婷,徐晓燕,向伟华.Broca失语患者语言加工偏侧化特征的脑磁图研究[J].中国康复医学杂志,2014,29(5):410~414 |
| Broca失语患者语言加工偏侧化特征的脑磁图研究 点此下载全文 |
| 祁冬晴 江钟立 林 枫 吴 婷 徐晓燕 向伟华 |
| 南京医科大学第一附属医院康复医学中心，南京，210029 |
| 基金项目：国家自然科学基金资助项目（81171854）；南京市卫生局资助项目（YKK11033） |
| DOI： |
| 摘要点击次数: 1753 |
| 全文下载次数: 1912 |
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| 摘要
目的：从时间和空间维度，应用脑磁图（MEG）研究探讨慢性恢复期Broca失语症患者图片命名语言加工的半球偏侧特征。
方法：选取未经言语训练的慢性恢复期Broca失语症患者及与其年龄、性别、受教育程度相匹配的右利手健康成人各5例，分别设为实验组和对照组。应用脑磁图（MEG）检测语言加工过程的神经活动。采用偏侧指数（LI）确定语言加工过程总体及特定感兴趣区（ROIs）的偏侧优势，选取LI≤-0.1表示右侧优势；LI≥0.1表示左侧优势。
结果：与对照组相比，语言加工全过程实验组总体ROIs呈右偏侧优势，差异具有显著性意义（P＜0.01）；语言加工子过程，实验组在275—400ms、400—600ms、600—800ms时间窗内总体ROIs呈右偏侧优势，差异具有显著性意义（P＜0.01）。具体ROIs水平，实验组Broca区、Wernicke区、缘上回、前运动区在既定的语言加工子过程中呈右偏侧优势，差异具有显著性意义（P＜0.05）。
结论：Broca失语患者图片命名语言加工过程呈右偏侧优势，右偏侧优势具有时间窗和脑区效应。 |
| 关键词：失语症 脑磁图 偏侧指数 语言加工 图片命名 |
| The spatiotemporal characteristics of language lateralization in Broca's aphasics: on magnetoencephalography study Download Fulltext |
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| The First Affiliated Hospital of Nanjing Medical University，Nanjing，210029 |
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| Abstract: |
| Abstract
Objective: To investigate the spatiotemporal characteristics of language lateralization during picture naming in chronic Broca's aphasics by magnetoencephalography(MEG).
Method: Five patients with chronic Broca's aphasia without speech-language therapy and five matched right-handed healthy controls were recruited. Spatiotemporal changing of language cortical activation during picture naming was detected by MEG. Language dominance was estimated by the laterality index (LI), which was defined to be left when the LI was more than 0.1, right when the LI was less than -0.1, and bilateral when the LI was between -0.1 and 0.1.
Result: Compared with the control group, the patient group has significantly right lateralization during the whole language processing of combined regions of interest(ROIs) (P＜0.01); At specific time window level, the patient group has significantly right lateralization during 275—400ms, 400—600ms and 600—800ms time windows (P＜0.01); At specific ROIs level, the patient group has significantly right lateralization in Broca's area, Wernicke's area, supramarginal gyrus and premotor area during the defined time windows (P＜0.05).
Conclusion: Chronic Broca's aphasics without speech-language therapy have significantly right lateralization during language processing of picture naming,which is associated with specific time window and regions of interest. |
| Keywords:aphasia magnetoencephalography laterality index language processing picture naming |
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