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燕兰云,王 蔚,沈飞飞,杨思雨,王 炜,汪 琴,王 彤,吴 婷.不同训练时间的有氧运动干预轻中度阿尔茨海默病的临床研究[J].中国康复医学杂志,2015,(8):771~776
不同训练时间的有氧运动干预轻中度阿尔茨海默病的临床研究    点此下载全文
燕兰云  王 蔚  沈飞飞  杨思雨  王 炜  汪 琴  王 彤  吴 婷
南京医科大学第一附属医院神经内科,210029
基金项目:国家自然科学基金(30901578);江苏省“六大人才高峰”第八批高层次人才资助项目项目;江苏省高校“青蓝工程”中青年学术带头人培养对象项目(JX2161015003);江苏省卫生厅“科教兴卫工程”重点人才项目(RC2011072);江苏省卫生厅“科教兴卫工程”开放课题(XK20 200905);苏州市科技局科技发展计划项目(SYSD2011044)
DOI:
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摘要:
      摘要 目的:探讨不同训练时间的有氧运动对轻中度阿尔茨海默病(AD)患者的作用。 方法:将54例AD患者随机分为有氧运动A组(18例)、有氧运动B组(18例)和对照组(18例),有氧运动组采用踩脚踏车的运动方式,接受强度为70%最大运动能力的有氧运动训练,A组每周2h训练,B组每周1h训练,持续6个月。分别在入组前、入组3个月、入组6个月时,采用MMSE、ADAS-cog、Barthel指数、NPI和NPI-D进行AD相关评价。 结果:A组有氧运动能明显改善患者的认知能力和精神神经症状,3个月和6个月时的MMSE评分从基线值19.1±3.1分别增加至21.4±2.5、24.2±1.8;ADAS-cog评分从基线值19.9±2.7分别降低至17.5±2.2、14.9±1.7;Barthel指数评分从基线值35.0±2.8分别增加至39.3±2.0、43.4±2.2;以上差异均有显著性意义(P<0.05)。NPI评分变化值3个月时为-1.8±5.2,6个月时为-1.6±4.2,后者有显著性意义(P<0.05);NPI-D评分变化值3个月和6个月分别为-1.9±3.1和-1.5±2.6,两者均有显著性差异(P<0.05)。B组仅在有氧运动早期(3个月时)可改善患者的认知功能(P<0.05),MMSE评分从基线值19.1±2.8增加至20.3±2.0,ADAS-cog评分从基线值20.1±2.5降低至18.3±2.5,对患者日常生活活动能力和精神神经症状无有益影响。Barthel指数与MMSE、ADAS-cog分值的变化无相关关系(r=0.136,r=0.77)。 结论:6个月的每周2h的有氧运动较3个月的有氧运动在改善AD患者的认知功能、生活能力、神经精神症状以及对照顾者的困扰评分方面获益较多。
关键词:阿尔茨海默病  有氧运动  认知能力
A clinical research of aerobic exercises with different training time in the treatment of mild to moderate Alzheimer’s disease    Download Fulltext
Department of Neurology,The First Affiliated Hospital of Nanjing Medical University,210029
Fund Project:
Abstract:
      Abstract Objective: To investigate the effect of aerobic exercises with different training time on mild to moderate Alzheimer's disease patients. Method: Fifty-four AD patients were divided into aerobic exercise group(A group and B group,18 patients separately)and control group(18 patients).A group was trained 2h per week,while B group was trained 1h per week,the training lasted 6 months. At the beginning,third month and sixth month of aerobic exercise,every patient was evaluated with MMSE,ADAS-cog, Barthel index, NPI and NPI-D. Result: After acrobic exercise in A group patient's cognitive ability and mental neurological symptoms improved obviously and the difference was statistically significant(P<0.05). After 3 months and 6months training,the MMSE scores from the baseline 9.1± 3.1 increased to 21.4±2.5 and 24.2±1.8 respectively, The ADAS-cog scores from the baseline 19.9±2.7 decreased to 17.5±2.2 and 14.9±1.7 respectively, BI scores from the baseline 35.0±2.8 increased to 39.3±2.0,43.4±2.2, at the end of the third month and sixth month,the changes of NPI scores were -1.8±5.2 and -1.6±4.2 respectively, compared with the baseline,the latter had significant difference(P<0.05), the changes of NPI-D scores were -1.9±3.1 and -1.5±2.6,both had significant differences(P<0.05). In B group patient's cognitive ability was improved just at the early phase(3 months). There was no correlation between BI and the changes of MMSE,ADAS-cog. Conclusion: AD patients after 2h per week aerobic exercise for 6 months could get more benefits on cognitive ability,activities of daily living,mental neurological symptoms and scores of caregivers compared to 3 months of aerobic exercise.
Keywords:Alzheimer's disease  aerobic exercise  cognitive ability
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