| 周 方,赵志刚,潘化平,王 磊.单次运动对轻度高血压患者血压、自主神经功能和氧化应激的影响[J].中国康复医学杂志,2015,(9):894~897 |
| 单次运动对轻度高血压患者血压、自主神经功能和氧化应激的影响 点此下载全文 |
| 周 方 赵志刚 潘化平 王 磊 |
| 南京中医药大学康复医学系，南京，210023 |
| 基金项目：全国高校博士点基金项目（20123237120008） |
| DOI： |
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| 摘要： |
| 摘要
目的：探索轻度高血压患者单次运动后体内自主神经功能和氧化应激的变化，及其与血压变化的关系。
方法：选取29例经过明确诊断的轻度原发性高血压患者。所有受试者进行心肺运动试验检测其峰值摄氧量VO2peak后，被安排以60% VO2peak进行40min踏车运动。运动前及运动后2h内，通过心脏超声检测左心室血流动力学指标，并计算体循环血管阻力（SVR）；肘前静脉采血，检测脂质过氧化物（LOOH）；用心电动态监测仪监测受试者的心率变异性（HRV）指标。
结果：与运动前相比，运动后受试者平均动脉压（MABP）降低（P＜0.05），SVR降低（P＜0.05），LOOH浓度升高（P＜0.05）。运动后心率变异性低频指标（LF）、低/高频比值（LF/HF）低于运动前（P＜0.05），高频指标（HF）、正常心搏间期标准差高于运动前（P＜0.05）。
结论：单次运动后血压下降，同时体循环血管阻力降低、自主神经功能改善、氧化应激增强。提示单次运动后血压的下降与体循环血管阻力降低、自主神经功能改善有关，而与氧化应激无关。 |
| 关键词：单次运动 高血压 氧化应激 自主神经功能 |
| Effects of a single exercise on blood pressure, autonomic function and redox regulation in hypertension patients Download Fulltext |
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| Nanjing University of Chinese Medicine, Nanjing, 210023 |
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| Abstract: |
| Abstract
Objective: To observe blood pressure, autonomic function and redox-mediated regulation post a single exercise in hypertension patients.
Method: Twenty-nine mild hypertension patients were studied following a single 40-min cycle exercise at 60% VO2peak after the maximal graded exercise test. The following measurements were administered pre-, immediately post-, 1-hour post- (P1) and 2-hours post- (P2) exercise: systemic vascular resistance (SVR) determined by mean arterial blood pressure (MABP)/cardiac output (CO) via echocardiography; lipid hydroperoxides (LOOH) via peripheral venous blood; heart rate variability (HRV) by ECG monitor.
Result: Compared with pre-exercise, there was significant decrease of MABP(P<0.05) as well as SVR (P＜0.05) and increase of LOOH concentration (P＜0.05) in hypertension patients after exercise. Meanwhile, the post-exercise low-frequency power (LF) and ratio of low-frequency to high-frequency power (LF/HF) decreased (P＜0.05), the post-exercise high-frequency power (HF) and standard deviation of NN intervals (SDNN) increased (P＜0.05).
Conclusion: A single exercise could result in attenuated blood pressure, reduced SVR, improved autonomic function and enhanced oxidative stress. It showed that the attenuated blood pressure following exercise was associated with reduced SVR and improved autonomic function, but independent of oxidative stress. |
| Keywords:single exercise hypertension oxidative stress autonomic function |
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