设为首页
加入收藏
联系我们
Email-Alert
 

    首页 | 杂志介绍 | 编委成员 | 审稿专家名录 | 投稿指南 | 订阅指南 | 过刊浏览 | 论著模板 | 综述模板 | 帮助

 
邵方方,尹大志,贾 杰,赵智勇,王想敏,郑晓慧,宋 凡,范明霞,孙莉敏.皮质下脑卒中对运动想象有关脑区功能连接的影响[J].中国康复医学杂志,2016,(2):133~139
皮质下脑卒中对运动想象有关脑区功能连接的影响    点此下载全文
邵方方  尹大志  贾 杰  赵智勇  王想敏  郑晓慧  宋 凡  范明霞  孙莉敏
华东师范大学,上海市磁共振重点实验室,上海,200062
基金项目:国家自然科学基金项目(面上81471651);上海市闸北区卫生局资助项目(面上2014MS06);上海市卫生和计划生育委员会资助项目(201440634);国家自然科学青年基金项目(81401859);国家科技部“十二五”支撑计划项目(2013BAI10B03)
DOI:
摘要点击次数: 654
全文下载次数: 735
摘要:
      摘要 目的:本研究拟运用静息态功能磁共振成像探讨皮质下脑卒中患者运动想象有关脑区功能连接状况。 方法:对24例病灶位于左侧运动通路的皮质下脑卒中患者和年龄、性别相匹配的24例正常对照进行静息态脑功能磁共振成像扫描,以病变侧(左侧)顶下小叶为种子点,计算它与其他脑区的功能连接,利用双样本t检验对比分析两组受试者静息态功能连接差异。 结果:与正常对照比较,脑卒中组的运动想象相关脑区之间功能连接发生显著变化。脑卒中组病变侧顶下小叶与病变对侧脑功能连接显著下降,涉及的脑区(顶下小叶、辅助运动皮质、运动前区、额下回岛盖部和枕中回)多于病变同侧(辅助运动皮质和运动前区);顶下小叶与病变同侧的额下回岛盖部和双侧小脑外侧部的功能连接显著增加。 结论:静息态磁共振成像功能连接分析成功显示皮质下脑卒中导致运动想象相关脑区功能连接受损的客观存在。
关键词:脑卒中  运动想象  顶下小叶  磁共振成像  静息态功能连接
The effect of subcortical stroke on motor imagery-related cortex functional connectivity    Download Fulltext
East China Normal University, Shanghai, 200062
Fund Project:
Abstract:
      Abstract Objective: To investigate motor imagery-related cortex functional connectivity of subcortical stroke patient, via task-based functional magnetic resonance imaging (fMRI). Method: Twenty-four patients with subcortical stroke on the left motor pathway and 24 health controls with matched gender and age were performed resting-state fMRI examination. Selecting the inferior parietal lobule as the seed point and calculating its functional connectivity with other cortex, the difference of resting-static functional connectivity between the two groups was calculated with paired t-test. Result: Comparing with heath controls, stroke patients showed significant variation of functional connectivity in motor imagery related brain areas. The decreased functional connectivity with the ipsilateral IPL located mainly in the contralateral cerebral hemisphere, including the inferior parietal lobe, supplementary area premotor cortex, pars opercularis of inferior frontal gyrus, and middle occipital gyrus. The decrease was less in the ipsilateral supplementary area and premotor cortex. Conversely, functional connectivity between the inferior parietal lobule and pars opercularis of inferior frontal gyrus and bilateral cerebellum increased in stroke patients. Conclusion: Impairment of motor imagery-related cortex functional connectivity in subcortical stroke patients was proved by resting-state fMRI functional connectivity analysis.
Keywords:stroke  motor imagery  inferior parietal lobe  magnetic resonance imaging  resting-state functional connectivity
查看全文  查看/发表评论  下载PDF阅读器

您是本站第 16453745 位访问者

版权所有:中国康复医学会
主管单位:国家卫生和计划生育委员会 主办单位:中国康复医学会
地址:北京市朝阳区樱花园东街,中日友好医院内   邮政编码:100029   电话:010-64218095   

本系统由北京勤云科技发展有限公司设计 京ICP备10000329号