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曹 蕾,谢毅凌,吴生海,周志宏,陈志鹏.低强度脉冲超声用于治疗骨腱连接点损伤及提高骨血管重建相关因子的研究[J].中国康复医学杂志,2017,(2):178~181
低强度脉冲超声用于治疗骨腱连接点损伤及提高骨血管重建相关因子的研究    点此下载全文
曹 蕾  谢毅凌  吴生海  周志宏  陈志鹏
湖南第一师范学院,长沙,410205
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DOI:
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摘要:
      摘要 目的:观察低强度脉冲超声(LIPUS)治疗骨-腱连接点(bone-tendon junction, BTJ)损伤的效果,及对骨血管重建相关因子的促进作用。 方法:选取BTJ损伤患者41例,采用LIPUS治疗2周。采用放射免疫法和酶联吸附免疫法(ELISA)检测碱性成纤维细胞生长因子(bFGF)、血小板衍生因子(PDGF)、血管内皮生长因子(VEGF)、转化生长因子-β(TGF-β)及基质金属蛋白酶-3(MMP-3)。采用疼痛视觉模拟评分(VAS)及功能指标变化,评价LIPUS的治疗效果。 结果:经LIPUS治疗2周后,血清中bFGF、PDGF、VEGF、TGF-β及MMP-3水平较治疗前均明显升高(P<0.05或P<0.01);VAS评分较治疗前明显下降[(7.42±1.89) vs (4.00±1.05) 分,t=8.492,P=0.000],Lysholm膝关节功能评分[(65.74±4.05) vs (83.69±8.25)分,t=5.114,P=0.000]、每分钟上下台阶次数[(24.81±5.19) vs (40.32±6.33) 次/min,t=15.333,P=0.000]及每日平均运动时间[(20.25±2.74) vs (72.30±8.52) min/d,t=14.305,P=0.000]均较治疗前明显升高(P=0.000)。每日平均运动时间随时间呈逐渐增高趋势,由72h开始,与治疗前比较,差异有显著性意义(P<0.01)。 结论:LIPUS治疗可提高骨血管重建相关因子水平,促进BTJ损伤恢复,效果显著。
关键词:低强度脉冲超声  骨腱连接点  骨血管重建
Effects of low intensity pulsed ultrasound stimulation on patella bone-tendon junction injury and vascularized bone reconstruction-related factors    Download Fulltext
Hunan First Normal University, Changsha,410205
Fund Project:
Abstract:
      Abstract Objective:To observe the effect of low intensity pulsed ultrasound stimulation(LIPUS) on bone-tendon junction(BTJ) injury and vascularized bone reconstruction-related factors. Method:A total of 41 patients with bone-tendon junction injury were selected, and the levels of PDGF, VEGF, TGF-β and MMP-3 were tested by radioimmunoassay and ELISA. The treatment effect was evaluated by visual analogue scale(VAS) and function indexs changed. Result:After two weeks treatment, the serum levels of bFGF, PDGF, VEGF, TGF-β and MMP-3 were increased significantly than that before treatment(P<0.05 or P<0.01).The score of VAS was reduced[(7.42±1.89) vs (4.00±1.05) score,t=8.492,P=0.000], Lysholm knee function score[(65.74±4.05) vs (83.69±8.25) score,t=5.114,P=0.000], the number of steps/min upward and forward[(24.81±5.19) vs (40.32±6.33) time/min,t=15.333,P=0.000] and the average sports time/day[(20.25±2.74) vs (72.30±8.52) min/d,t=14.305,P=0.000] were significantly enhanced(P=0.000). Moreover, the average sports time/day was increased along with time, and from 72h, the difference has statistic significance compared with that before treatment (P<0.01). Conclusion:LIPUS can improve the level of bone vascular remodeling-related factors and promote the BTJ injury recovery.
Keywords:low intensity pulsed ultrasound stimulation  Bone-tendon junction  vascularized bone reconstruction
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