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陈国仙,王国荣,李国山,林宗锦,杨俊华,林国勇,曾清东.低强度复合振动联合阿仑膦酸钠对绝经后骨质疏松患者骨密度的影响研究[J].中国康复医学杂志,2017,(2):182~186
低强度复合振动联合阿仑膦酸钠对绝经后骨质疏松患者骨密度的影响研究    点此下载全文
陈国仙  王国荣  李国山  林宗锦  杨俊华  林国勇  曾清东
莆田市第一医院骨科,莆田,351100
基金项目:福建省医学创新课题资助项目(2014-CXB-31);福建莆田市科技局资助项目(2012S01)
DOI:
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摘要:
      摘要 目的:观察低强度全身复合振动(whole-body vibration,WBV)联合阿仑膦酸钠(alendronate,ALE)对绝经后骨质疏松患者骨密度的影响情况。 方法:选择2014年8—12月门诊绝经后骨质疏松患者60例,随机分为WBV治疗组、ALE治疗组和WBV+ALE治疗组,每组20例;WBV治疗组是给予全身低强度复合振动(振动强度为0.5—0.8g,频率为45—55Hz,每次振动30min,每天1次,每周5次,周末休息2天,共6个月);ALE治疗组是每周口服1次阿仑膦酸钠70mg;WBV+ALE治疗组是给予全身复合振动及阿仑膦酸钠治疗。然后使用双能X线吸收骨密度仪测定所有志愿者治疗前后腰椎及髋部的骨密度。 结果:①腰椎骨密度在WBV治疗6个月后增加3.72%,ALE治疗组增加4.55%,WBV+ALE治疗组增加7.16%,三组治疗方法之间有显著性差异(P<0.05)。②髋部Neck骨密度,WBV治疗6个月后增加2.24%,ALE治疗组增加3.43%,WBV+ALE治疗组增加7.22%,三组治疗方法比较有显著性差异(P<0.05)。③大转子骨密度,WBV治疗6个月后增加2.10%,ALE治疗组增加4.90%,WBV+ALE治疗组增加7.63%,三组治疗方法之间比较有显著性差异(P<0.05)。④髋部Wards三角骨密度,WBV治疗6个月后增加5.00%,ALE治疗组增加7.13%,WBV+ALE治疗组增加9.04%,三组治疗方法之间比较有显著性差异(P<0.05)。 结论:WBV、ALE和WBV+ALE三种治疗方法均能改善绝经后老年妇女腰椎及髋部的骨密度,其中低强度WBV联合ALE能够更好提高绝经后腰椎及髋部BMD,可以为临床上绝经后骨质疏松的防治工作提供一种新的思路。
关键词:全身复合振动  阿仑膦酸钠  骨质疏松症  绝经后妇女  骨密度
Clinical observation of low-magnitude whole-body vibration combined with Alendronate on bone mineral density in women with postmenopausal osteoporosis    Download Fulltext
Department of Orthopedic, the First Hospital of Putian City, Fujian Province, Putian, 351100
Fund Project:
Abstract:
      Abstract Objective: To observe the bone mineral density for patients with postmenopausal osteoporosis treated by low-magnitude whole-body vibration and alendronate. Method: A total of sixty postmenopausal osteoporotic women were randomly divided into three groups (WBV n=20, ALE n=20 and WBV+ALE n=20). The level of WBV applied was 0.5—0.8 g at 45—55 Hz for 6 months(30min/d, 5d/week). ALE was administered in dose of 70 mg once a week. The BMD of lumbar (L2—L4), femoral neck, anter, and wards triangle region of hip was determined by dual-energy X-ray absorptiometry before and after treatment. Result: ① The BMD in lumbar 2—4 after 6-months treatment showed that the average BMD was increased by 3.72% in WBV-group, by 4.55% in ALE-group, and by 7.16% in WBV+ALE-group. There were significant differences among three groups (P<0.05). ② The BMD in femoral neck after 6-months treatment showed that the average BMD was increased by 2.24% in WBV-group, by 3.43% in ALE-group, and by 7.22% in WBV+ALE-group. There were significant differences among three groups (P<0.05). ③The BMD in anter of hip after 6-months treatment showed that the average BMD was increased by 2.10% in WBV-group, by 4.90% in ALE-group, and by 7.63% in WBV+ALE-group. There were significant differences among three groups (P<0.05). ④ The BMD in wards triangle region of hip after 6-months treatment showed that the average BMD was increased by 5.00% in WBV-group, by 7.13% in ALE-group, and by 9.04% in WBV+ALE-group. There were also significant differences among three groups (P<0.05). Conclusion: Whole-body vibration, alendronate and combination treatment can increase the BMD in postmenopausal osteoporotic women, significantly. Furthermore, whole-body vibration combined with alendronate was more effective in improving the BMD in postmenopausal women.
Keywords:whole-body vibration  Alendronate  osteoporosis  postmenopausal women  bone mineral density
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