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李 冉,杜巨豹,张 晔,郝建会,宋为群.唤名相关P300在非急性期意识障碍评估及预后预测中的临床价值[J].中国康复医学杂志,2018,(3):292~296
唤名相关P300在非急性期意识障碍评估及预后预测中的临床价值    点此下载全文
李 冉  杜巨豹  张 晔  郝建会  宋为群
首都医科大学宣武医院康复医学科,北京,100053
基金项目:国家自然科学基金资助项目(81371194,30770714);首都医学发展科研基金资助项目(2007-2008);北京市卫生系统高层次卫生技术人才培养计划资助项目(2009-3-62)
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摘要:
      摘要 目的:探讨唤名相关的P300在非急性期意识障碍残余意识评估及预后预测中的临床价值。 方法:对9例植物状态(VS)患者及7例最小意识状态(MCS)患者进行事件相关电位(ERP)研究,使用了两组不同难度的Oddball程序:第一组(正名组)使用纯音和受试者本人名字(正名)做标准刺激和偏差刺激,第二组(正反名组)使用受试者本人的衍生名字(反名)和受试者本人名字(正名)做标准刺激和偏差刺激,比较两组刺激诱发的P300在意识障碍患者中的出现率及其与预后之间的关系。 结果:①MCS较VS患者两组同时出现P300的可能性较大(P<0.05);②两组同时出现P300者在随访期间均恢复意识,反之恢复意识的可能性较小。 结论:与既往研究仅使用正名组刺激或使用其他刺激相比,本研究中正名组联合正反名组诱发的P300可有效识别意识障碍患者的残余意识,并与预后相关。
关键词:意识障碍  最小意识状态  植物状态  P300  受试者名字
Clinical assessment and prognosis prediction of chronic unconscious patients with P300 elicited by the names    Download Fulltext
Xuanwu Hospital, Capital Medical University, Beijing,100053
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Abstract:
      Abstract Objective:To investigate the clinical value of P300 elicited by the names in the assessment and prognosis prediction of chronic disorders of consciousness patients. Method: Event-related potential were studied in nine vegetative state patients and seven minimally conscious state patients, using two Oddball paradigms: the first one used the tone and subject's own name as the standard and deviant stimuli, the second one used subject's derived name and subject's own name as the standard and deviant stimuli. We compared the occurrence rate of P300 in vegetative state and minimally conscious state patients and the relationship between P300 and prognosis. Result:①P300 was more likely to appear in MCS than VS patients (P<0.05). ②Patients who have P300 in these two groups regained consciousness during the follow-up period, on the contrary, it was difficult to be conscious. Conclusion:Compared with previous studies with the first Oddball paradigm only or other stimuli, we might evaluate the residual conscious and predict their prognosis effectively together with the second one.
Keywords:disorders of consciousness  minimally conscious state  vegetative state  P300  subject's own name
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