| 谢圣明,师晓燕,倪 宏.长程的运动训练对新生期大鼠反复惊厥所致学习和记忆损害的影响[J].中国康复医学杂志,2018,(6):653~657 |
| 长程的运动训练对新生期大鼠反复惊厥所致学习和记忆损害的影响 点此下载全文 |
| 谢圣明 师晓燕 倪 宏 |
| 苏州大学附属儿童医院，苏州，215003 |
| 基金项目：国家自然科学资金资助项目（81471337；81301129） |
| DOI： |
| 摘要点击次数: 1214 |
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| 摘要
目的：探讨早期长程跑步运动对新生期大鼠反复惊厥发作引起的学习记忆障碍的干预作用。
方法：18只8日龄（P8）SD大鼠依据随机数字表法分成空白对照组（CONT）、惊厥组（EXP1）及惊厥加运动训练组（EXP2），每组各6只。适应性喂养1天后，EXP1组和EXP2组于P9吸入三氟乙醚诱导惊厥发作，连续诱导7d，CONT组同样操作但不吸入三氟乙醚。三组大鼠于P58—P64进行水迷宫测试以检测各组大鼠的学习记忆能力，其间于P16—P57 EXP2组大鼠进行跑台运动训练。
结果：①水迷宫定向航行实验显示：三组大鼠水迷宫逃避潜伏期存在组间显著性差异[F=429.90，P＜0.05]，训练天数显著性差异[F=282.30，P＜0.05]以及组间因素与训练天数的交互作用的显著性差异[F=12.71，P＜0.05]，差异具有显著性意义。EXP2组大鼠逃避潜伏期较EXP1组大鼠均明显缩短（P＜0.05），EXP2组大鼠与CONT组大鼠比较无显著性差异（P＞0.05），趋于正常。②空间探索实验：EXP2组大鼠较EXP1组大鼠穿越平台次数明显增多（P＜0.05），EXP2组大鼠与CONT组大鼠比较无显著性差异（P＞0.05），趋于正常。
结论：运动训练能够明显减少反复惊厥组大鼠逃避潜伏期时间，增加穿越平台次数，这有可能是由于运动训练改善了惊厥大鼠学习记忆能力所导致的。 |
| 关键词：惊厥 水迷宫 运动训练 学习记忆 |
| Effects of long-term physical exercise on learning and memory impairment induced by recurrent seizures in neonatal rats Download Fulltext |
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| Soochow University Affiliated Children's Hospital, Soochow, 215003 |
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| Abstract: |
| Abstract
Objective: To explore effects of early long-term exercise training on learning and memory impairment induced by recurrent seizures in neonatal rats.
Method: Eighteen Sprague-Dawley rats at postnatal days 8 (P8) were randomly divided into control group (CONT), convulsion group (EXP1), and convulsion plus physical exercise group (EXP2)（Six in each group）. Rats were fed for 1 day before the study. From P9, rats in EXP1 and EXP2 were subjected to flurothyl induced recurrent seizures 30min daily for 7 days. The rats of EXP2 were physical exercise from P16 to P57. The rats in control group were placed into the container for an equal amount of time to their counterpart without exposing to flurothyl. On P58—P64, subjects of the three groups were tested with Morris water maze.
Result: ①Place navigation test: there were significant differences among three groups [F= 429.90, P＜0.05], day [F=282.30, P＜0.05], interaction [F=12.71, P＜0.05] by repeated two-way ANOVA analysis. Compared with CONT group, the escape latency in EXP1 was longer (P＜0.05). Compared with EXP1, the escape latency in EXP2 was shorter (P＜0.05). ②Spatial probe test: Compared with CONT group, the frequency of passing through the platform in EXP1 was much less (P＜0.05). While compared with EXP1, the frequency of passing through the platform in EXP2 was much more (P＜0.05).
Conclusion: Physical exercise could significantly reduce the escape latency time and increase the number of crossing the platform in the recurrent seizure group, which may be due to the improvement of learning and memory ability of convulsive rats by physical exercise. |
| Keywords:convulsion morris water maze physical exercise learning and memory |
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