| 石晓丽,杨月琴,金 丽.有氧运动通过胃促生长素调节肥胖及肥胖抵抗大鼠摄食量的研究[J].中国康复医学杂志,2018,(6):663~668 |
| 有氧运动通过胃促生长素调节肥胖及肥胖抵抗大鼠摄食量的研究 点此下载全文 |
| 石晓丽 杨月琴 金 丽 |
| 武汉体育学院研究生院 湖北省运动训练监控重点实验室，武汉，430079 |
| 基金项目：国家体育总局科研课题（2015B089）；霍英东教育基金会青年教师基金基础性研究课题（121103） |
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| 摘要
目的：探讨有氧运动对肥胖及肥胖抵抗大鼠摄食量的影响及机制。
方法：4周龄雄性Sprague-Dawley大鼠，随机分为普饲对照组（C组）和高脂饲料组，饲养10周后，筛选出高脂饮食诱导的肥胖组（OB组）大鼠和肥胖抵抗组（OR组）大鼠。再分别将OB组和OR组随机分为运动组（OB-Sw组，OR-Sw组）大鼠和非运动组（OB-Sed组，OR-Sed组）大鼠，运动组大鼠进行8周60%的个体力竭强度的有氧游泳运动，45min/d，5次/周，每周监测大鼠体重和摄食量。8周干预结束后，取血清和胃组织，血清检测TG、TC、LDL-c、HDL-c，胃组织检测促生长素（Ghrelin）表达情况。
结果：10周后，高脂饲料组大鼠体重与普饲对照组相比，显著性增高（P＜0.05）；OB-Sed组大鼠的血清低密度脂蛋白（LDL）与C组的相比，显著性增高（P＜0.05）；通过8周的有氧运动，OB-Sed组大鼠的相对摄食量多于OB-Sw组，OR-Sed组大鼠的相对摄食量多于OR-Sw组；OB-Sed组、OR-Sed组大鼠胃组织Ghrelin表达程度高于OB-Sw组、OR-Sw组和C组。
结论：运动可通过降低大鼠胃组织Ghrelin的表达来降低摄食量。 |
| 关键词：高脂饮食 有氧游泳运动 肥胖 肥胖抵抗 胃促生长素 |
| Effects of aerobic exercise on the food intake of obesity rats and obesity resistant rats by regulating the expression of ghrelin in stomach Download Fulltext |
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| Graduate School, Wuhan Sports University, Wuhan, 430079 |
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| Abstract: |
| Abstract
Objective: To explore the effect of aerobic exercise on the food intake of obesity rats and obesity resistant rats and some mechanisms
Method: The four years old Sprague-Dawley rats were randomly divided into standard chow group (C) and high-fat diet group. After 10 weeks feeding, the obese group (OB group) and obesity resistant group (OR group) induced by high-fat diet were screened out. Then all the rats in OB group and OR group were respectively and randomly divided into exercise rats (OB-Sw group, OR-Sw group) and non-exercise rats (OB-Sed group, OR-Sed group). Aerobic swimming exercise for the exercise rats was defined as 60% of individual exhaustion exercise intensity, 45 minutes per day, 5 times per week. Meanwhile, the body weight and food intake of the exercise and non-exercise rats were monitored every week. After 8 weeks intervention, the serum and gastric tissue of rats were obtained, and then the TG, TC, LDL-c, HDL-c in serum and the expression of ghrelin in gastric tissue were detected.
Result: Ten weeks later, the body weight of the rats with high-fat diet showed a significant difference compared with the rats with standard chow group (P＜0.05). The content of LDL in OB-Sed group was significantly higher than that in C group (P＜0.05). After 8 weeks aerobic exercise, for the food intake, OB-Sed group was higher than OB-Sw group and OR-Sed group was higher than OB-Sw group. The expression of ghrelin in gastric tissue in OB-Sed group and OR-Sed group was higher than that in OB-Sw group, OB-Sw group and C group.
Conclusion: Exercise might reduce the food intake of obesity rats and obesity resistant rats by reducing the expression of ghrelin in stomach. |
| Keywords:high-fat diet aerobic swimming exercise obesity obesity resistant ghrelin |
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