| 张嘉玮,陈 英,邓伟丽,刘文静,徐凯月,万春晓.间歇性低压氧通过δ-阿片类受体表达保护心肌梗死大鼠心肌的研究[J].中国康复医学杂志,2020,(7):782~786 |
| 间歇性低压氧通过δ-阿片类受体表达保护心肌梗死大鼠心肌的研究 点此下载全文 |
| 张嘉玮 陈 英 邓伟丽 刘文静 徐凯月 万春晓 |
| 天津医科大学，天津市，300052 |
| 基金项目：天津市自然科学基金项目(18JCZDJC98900)；天津市卫计委项目（16KJ122） |
| DOI：10.3969/j.issn.1001-1242.2020.07.004 |
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| 摘要： |
| 摘要
目的：研究间歇性低压氧 (intermittent hypobaric hypoxia，IHH) 能否提高δ-阿片类受体（delta-opioid receptor，DOR）的表达，对大鼠心肌梗死(myocardial infarction，MI)后心肌产生保护作用。
方法：24只SD大鼠随机分为假手术常氧干预组(Sham-Nor)、假手术低压氧干预组(Sham-IHH)、心梗常氧干预组(MI-Nor)和心梗低压氧干预组(MI-IHH)。心肌梗死造模1周后进行干预。4周后检测心脏重量指数、心肌纤维化程度、超声检测心脏功能及DOR蛋白表达。
结果：4周后，MI-IHH和MI-Nor组相比：心脏重量无显著性差异(P>0.05)，MI-IHH组心肌纤维化显著减少(P<0.05)、左室收缩末内径(left ventricular end systolic diameter，LVESd)明显下降(P<0.01)、左室射血分数(left ventricular ejection fraction，LVEF)显著提高(P<0.001)、DOR显著增加(P<0.05)，MI-Nor和MI-IHH组中DOR表达与LVEF呈正相关(P<0.05)。
结论：IHH能够通过提高大鼠DOR的表达产生心肌梗死后心肌保护作用。 |
| 关键词：间歇性低压氧 心肌梗死 左心室重构 δ-阿片类受体 |
| Study on intermittent hypobaric hypoxia protection of myocardial infarction rats by δ-opioid receptor expression Download Fulltext |
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| Tianjin Medical University， Tianjin， 300052 |
| Fund Project: |
| Abstract: |
| Abstract
Objective: To find out whether intermittent hypobaric hypoxia can increase the expression of delta-opioid receptor (DOR) and protect myocardium after myocardial infarction in rats.
Method: Twenty-four rats were randomly divided into four groups: Sham-Nor group， Sham-IHH group， MI-Nor group and MI-IHH group. One week after left anterior descending coronary artery ligation， rats were exposed to different treatments. After 4 weeks’ treatment， the heart weight ratio， myocardial fibrosis area， cardiac function detected by echocardiography and delta-opioid receptor (DOR) expression were measured.
Result: Four weeks later， there was no difference in heart weight ratio between MI-Nor group and MI-IHH group (P>0.05). Compared with MI-Nor group， myocardial fibrosis area decreased(P<0.05)，left ventricular end systolic diameter (LVESd) decreased(P<0.01)， left ventricular ejection fraction (LVEF) increased(P<0.001) and DOR expression elevated(P<0.05) in MI-IHH group. DOR expressions were positive relate to LVEF in MI-Nor group and MI-IHH group(P<0.05).
Conclusion: IHH can protect myocardium after myocardial infarction by increasing DOR expression in rats. |
| Keywords:intermittent hypobaric hypoxia myocardial infarction left ventricular remodeling delta-opioid receptor |
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