| 朱光跃,郑 娅,徐 榕,孙婷婷,毛梦钗,许东升.基于功能近红外光谱技术的高频重复磁刺激干预外周神经对皮层血流动力学反应的影响[J].中国康复医学杂志,2021,(8):938~942 |
| 基于功能近红外光谱技术的高频重复磁刺激干预外周神经对皮层血流动力学反应的影响 点此下载全文 |
| 朱光跃 郑 娅 徐 榕 孙婷婷 毛梦钗 许东升 |
| 同济大学附属同济医院康复中心，上海市，200065 |
| 基金项目：国家重点研发计划（2020YFC2004202） |
| DOI：10.3969/j.issn.1001-1242.2021.08.006 |
| 摘要点击次数: 1047 |
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| 摘要： |
| 摘要
目的：通过磁刺激干预外周神经的同时使用功能近红外光谱技术（fNIRs）记录脑皮层光学信号改变，探索外周神经刺激与皮层功能近红外信号反应的相关性。
方法：本研究纳入健康成年人8例，使用15Hz，2.7T强度刺激受试者手部。研究采用Block设计，刺激10s，休息20s，共重复刺激5次。同时使用fNIRs监测受试者脑皮层信号的变化。每个受试者在接受真正刺激前，先进行一组假刺激作为对照。
结果：在健康成年人中，外周磁刺激可引起感觉-运动皮层血流动力学响应变化，该现象在假刺激组未出现（P＞0.05，未矫正）。在进行偏侧手刺激时，多个受试者感觉-运动所在脑区（通道23、24、27、28、42、44、45、48）信号刺激时较刺激间歇有显著差异（P＜0.05，未矫正），且皮层血流动力学响应具有偏侧性。
结论：fNIRs可以实时反映外周神经磁刺激引起的皮层血流动力学响应变化。rTMS-fNIRs实时监测模式提供了外周神经磁刺激时脑皮层的局部脑皮质脑激活的评估方法，这对于研究外周神经磁刺激干预与脑区激活的量效关系具有重要意义。 |
| 关键词：功能近红外光谱技术 经颅磁刺激 外周神经磁刺激 血流动力学 皮层兴奋性 |
| Cortical hemoglobin-concentration changes under the coil induced by peripheral nerve magnetic stimulation in humans： A simultaneous recording with near-infrared spectroscopy Download Fulltext |
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| Rehabilitation Center，Tongji Hospital，Tongji University，Shanghai，200065 |
| Fund Project: |
| Abstract: |
| Abstract
Objective： To explore the correlation between peripheral nerve stimulation and cortical functional near-infrared signal response by using functional near-infrared and to record the changes of cortical optical signal while magnetic stimulation intervenes peripheral nerve.
Method： A total of 8 healthy adults were enrolled in this study， the hands of whom were stimulated with 15Hz， 2.7T intensity. The mode of stimulation was the block design with 10-second stimulation， 20-second rest， and a total of 5 repetitions of stimulation. Simultaneously， functional near-infrared was adopted to monitor the changes of the subject’s cerebral cortex signal. Before implementing the real stimulation， a sham one will be taken firstly.
Result： In healthy adults， peripheral magnetic stimulation can induce extensive hemodynamic response of the sensory-motor cortex， which did not appear in the sham stimulation group. When stimulating the lateral hands， the signals during stimulation of multiple brain regions were significantly different with the intermittent stimulation (P<0.05， uncorrected)， and the cortical hemodynamic responses exhibited lateral feature.
Conclusion：FNIRs can reflect the changes of cortical hemodynamics induced by peripheral nerve magnetic stimulation in real time. The real-time monitoring mode of rTMS-fNIRs provides an assessment method for the local cortical brain activation and brain network connection of the cerebral cortex during peripheral nerve magnetic stimulation, which is of great significance for studying the dose-effect relationship between peripheral nerve magnetic stimulation intervention and brain activation. This study also provides a real-time monitoring and evaluating model for promoting cortical excitability through intervention in the periphery. |
| Keywords:functional near-infrared spectroscopy transcranial magnetic stimulation peripheral nerve magnetic stimulation hemodynamics cortical excitability |
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