| 黄琴蓉,周炫孜,李建佑,肖 农.口服巴氯芬治疗痉挛型脑性瘫痪患儿痉挛的临床疗效研究[J].中国康复医学杂志,2022,(3):331~335 |
| 口服巴氯芬治疗痉挛型脑性瘫痪患儿痉挛的临床疗效研究 点此下载全文 |
| 黄琴蓉 周炫孜 李建佑 肖 农 |
| 重庆医科大学附属儿童医院康复科，儿童发育疾病研究教育部重点实验室，国家儿童健康与疾病临床医学研究中心，儿童发育重大疾病国家国际科技合作基地，儿科学重庆市重点实验室，重庆市，400014 |
| 基金项目： |
| DOI：10.3969/j.issn.1001-1242.2022.03.007 |
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| 摘要： |
| 摘要
目的：观察口服巴氯芬治疗痉挛型脑性瘫痪患儿痉挛的临床疗效。
方法：回顾性分析60例痉挛型脑性瘫痪痉挛的康复治疗疗效，其中试验组和对照组各30例，两组常规康复治疗相同，试验组在常规康复治疗基础上口服巴氯芬（1-2mg/kg/d，q8h）治疗。用改良Ashworth量表（MAS）评估痉挛程度，分别记录两组患者治疗前、治疗2周和治疗4周MAS变化情况。
结果：两组患者一般资料差异无显著性意义（P＞0.05）。治疗前两组MAS评分无显著性差异（P＞0.05）。治疗2周及4周后，与对照组相比，试验组MAS评分下降，两组MAS评分差异有显著性意义（P＜0.05）。试验组治疗2周、治疗4周总有效率为73.3%、93.3%，与对照组相比，有显著性差异（P＜0.05）。试验组约20%（6/30）发生轻度不良反应（嗜睡3例、乏力5例）。
结论：口服巴氯芬能有效的缓解痉挛型脑瘫患儿的痉挛程度，且无严重不良反应，值得推广。 |
| 关键词：巴氯芬 口服 脑性瘫痪 痉挛 改良Ashworth量表 |
| Efficacy of oral Baclofen on spasticity in children with spastic cerebral palsy Download Fulltext |
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| Department of Rehabilitation， Children's Hospital of Chongqing Medical University, 400014 |
| Fund Project: |
| Abstract: |
| Abstract：
Objective： To evaluate the effect of oral Baclofen on spasticity in children with spastic cerebral palsy.
Method： Clinical data of 60 children with spastic cerebral palsy were retrospective analyzed， including experimental group (n=30) and control group (n=30). The regular rehabilitation treatments applied daily to both groups were the same. The experimental group was combined with oral Baclofen 1-2mg/kg/d，q8h. Modified Ashworth Scale (MAS) was used as the measurement of spasticity，the scores of MAS were recorded before treatment and after 2 weeks treatment and 4 weeks treatment.
Result： There were no significant difference between the two groups for general data and baseline of MAS before treatment (P＞0.05). Compared with the control group， the MAS scores of the experimental group decreased more after 2 weeks treatment and 4 weeks treatment， the difference between the two groups was significant (P<0.05). The total effective rates of the experimental group after 2 weeks and 4 weeks treatment were 73.3% and 93.3%。 there were significant differences with the control group (P<0.05). About 20% (6/30) of the experimental group had mild adverse reactions (3 cases of drowsiness and 5 cases of fatigue).
Conclusion： Short period oral Baclofen could effectively relieve spasticity of children with spastic cerebral palsy without serious adverse reactions， and is worthy of promoting. |
| Keywords:Baclofen oral cerebral palsy spasticity modified Ashworth spasm scale |
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