| 邰佳慧,李浩正,王婷玮,吴军发.基于功能性近红外光谱技术的吞咽相关任务大脑皮质功能偏侧化研究[J].中国康复医学杂志,2022,(5):594~599 |
| 基于功能性近红外光谱技术的吞咽相关任务大脑皮质功能偏侧化研究 点此下载全文 |
| 邰佳慧 李浩正 王婷玮 吴军发 |
| 复旦大学附属华山医院康复医学科，上海市，200040 |
| 基金项目：国家重点研发计划（2018YFC2001700）；上海市科学技术委员会项目资助（19411968700，20412420200）；上海市临床重点专科项目（shslczdzk02702） |
| DOI：10.3969/j.issn.1001-1242.2022.05.004 |
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| 摘要： |
| 摘要
目的：采用功能性近红外光谱技术（fNIRS）研究吞咽相关任务时大脑皮质激活及偏侧化情况。
方法：纳入22名健康成年被试，在fNIRS采集过程中执行咀嚼及舌尖滑动任务，对任务激活脑区进行分析，并计算不同脑区的偏侧化指数。
结果：在执行咀嚼任务时，左侧初级运动皮层（primary motor cortex，PMC）、左侧初级躯体感觉皮层（primary somatosensory cortex， PSC）、左侧运动前区/运动辅助区（pre-motor and supplementary motor cortex，pSMC）、左侧缘上回（supramarginal gyrus， SMG），右侧背外侧前额叶（dorsolateral prefrontal cortex，DLPFC）、右侧额叶眼动区（frontal eye fields， FEF）、右侧颞上回（superior temporal gyrus，STG）及颞中回（middle temporal gyrus，MTG）、右侧额极区（frontopolar area， FPA）及右侧额下回三角区（pars triangularis， PTG）脑区明显激活。舌尖滑动任务则表现为双侧PMC、双侧PSC、双侧pSMC及左侧SMG脑区明显激活。同时在全脑及PMC、pSMC、PSC等脑区的激活呈现偏侧化模式。咀嚼任务主要表现为局部脑区的左侧偏侧化激活，舌尖滑动任务表现为局部脑区的右侧偏侧化激活。全脑左右半球间的偏侧化变异性较大，且与利手无关。
结论：fNIRS可应用于吞咽相关的脑功能研究。PMC、pSMC、PSC、SMG、STG、MTG、PTG等脑区与吞咽特定过程的神经调控有关，并表现为偏侧化激活模式，并且随着吞咽活动的进行，相关脑区的激活可能存在从左侧逐渐向右侧偏侧化的转变。 |
| 关键词：吞咽 功能性近红外光谱技术 偏侧化 |
| Lateralization of cerebral cortex function in swallowing related tasks： A functional near-infrared spectroscopy study Download Fulltext |
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| Huashan Hospital，Fudan University，Shanghai，200040 |
| Fund Project: |
| Abstract: |
| Abstract
Objective： Functional near-infrared spectroscopy(fNIRS) was used as an imaging tool to study cerebral cortex activation and lateralization during swallowing related tasks.
Method： A total of 22 healthy subjects were enrolled to perform chewing and tongue tip sliding tasks during fNIRS measure. The brain regions activated by the task were analyzed and the lateralization index of different brain regions was calculated.
Result： Bilateral primary motor cortex(PMC)， premotor and supplementary motor cortex(pSMC)， primary somatosensory cortex(PSC) and left supramarginal gyrus(SMG) were significantly activated. Right dorsolateral prefrontal cortex(DLPFC)， frontal eye fields(FEF)， superior temporal gyrus(STG)， middle temporal gyrus(MTG)， frontopolar area(FPA) and pars triangularis(PTG) were also found to be activated in the chewing task. Brain activation exhibited lateralized mode in whole cortex and PMC， pSMC， PSC and other brain regions. Left-lateral activation of several brain regions was demonstrated in the chewing task， while right-lateral activation of brain regions was found in the tongue tip sliding task. The lateralization between the left or right hemispheres of the whole brain has variability and had no correlation with handedness.
Conclusion： fNIRS can be used to study the brain function related to swallowing. To some extent， it suggests the cortical central of swallowing function and shows a lateralization activation pattern in healthy people. |
| Keywords:swallowing functional near-infrared spectroscopy lateralization |
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