| 田 婧,范晨雨,李浩正,吴 毅.基于功能性近红外光谱技术的脑卒中后运动功能障碍患者脑网络功能连接研究[J].中国康复医学杂志,2022,(5):600~605 |
| 基于功能性近红外光谱技术的脑卒中后运动功能障碍患者脑网络功能连接研究 点此下载全文 |
| 田 婧 范晨雨 李浩正 吴 毅 |
| 复旦大学附属华山医院康复医学科，上海市，200040 |
| 基金项目：国家重点研发计划项目资助（2018YFC2001700）；上海市科学技术委员会项目资助（20412420200）；上海市临床重点专科项目资助（shslczdzk02702） |
| DOI：10.3969/j.issn.1001-1242.2022.05.005 |
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| 摘要： |
| 摘要
目的：采用功能性近红外光谱技术（fNIRS）对比观察运动功能障碍的脑卒中患者与健康人的静息态脑功能连接差异。
方法：应用fNIRS分析20例左侧、20例右侧脑卒中后运动功能障碍患者及20例健康对照组静息状态下各脑区之间功能连接强度，并在前额叶（prefrontal cortex，PFC）、第一躯体运动区（M1）、初级躯体感觉皮层区（primary somatosensory cortex，PSC）中比较组间差异。
结果：基于氧合血红蛋白情况下，左右脑卒中组的全脑功能连接平均强度均低于健康组；同源比较中左侧脑卒中组与左侧M1区（患侧）的功能连接强度与健康组有显著性差异（P＜0.05），其余兴趣区（ROI）与健康组无明显差异。右脑卒中组的左侧PFC、左侧M1区（健侧）的功能连接强度与健康组有显著性差异（P＜0.05），其余ROI与健康组无明显差异。异源比较中左脑卒中组和右脑卒中组与健康组相比左侧M1与右侧M1区间的功能连接强度差异有显著性意义（P<0.05），提示与健康组相比，左右脑卒中组的患者的双侧大脑半球间即健侧和患侧半球间M1区间的功能连接强度有明显减弱。另外，相较于健康组，右脑卒中组在左右半球PFC间的功能连接强度也有显著性意义（P<0.05）；而左脑卒中组则没有显著性差异（P＞0.05）。其他ROI功能区间功能连接均无显著性差异（P＞0.05）。左右脑卒中组的PFC区、M1区与FMA评分以及Brunnstrom分期之间的相关性没有显著性差异（P＞0.05）。
结论：在采用功能性近红外脑功能成像的静息态脑功能连接研究中，左右脑卒中组的全脑功能连接平均强度均低于健康组；其中左脑卒中组的患侧M1区功能连接低于健康组，而在左右半球间的功能连接中左右脑卒中组的两侧半球M1区间的功能连接均减少，右脑卒中组的两侧半球PFC区间的功能连接减少。 |
| 关键词：功能性近红外光谱技术 脑网络 静息态 脑功能连接 |
| Functional connectivity in patients with motor dysfunction after stroke by functional near-infrared spectroscopy Download Fulltext |
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| Department of Rehabilitation Medicine，Huashan Hospital，Fudan University，Shanghai，200040 |
| Fund Project: |
| Abstract: |
| Abstract
Objective： Functional near-infrared spectroscopy (fNIRS) was used to observe the differences of resting-state functional brain connectivity between stroke patients with motor dysfunction and healthy people.
Method： fNIRS was used to analyze the functional connection strength between brain regions in 20 patients with post-left stroke motor dysfunction, 20 patients with post-right stroke motor dysfunction and 20 healthy controls. The differences between three groups were compared in the prefrontal cortex(PFC)、M1 and primary somatosensory cortex (PSC).
Result： Based on oxygenated hemoglobin， the average strength of whole brain functional connection in the left or right stroke groups was lower than that in the healthy group. In homologous comparison， the functional connection strength between the left stroke group and the left M1 area (affected side) was significantly different from that of the healthy group (P<0.05). However, there was no significant difference in the other ROI between the left stroke group and the healthy group. There was a significant difference in the functional connection strength of left PFC and left M1 area (healthy side) between the right stroke group and the healthy group (P<0.05)， and there was no significant difference in the other ROI between the right stroke group and the healthy group. In heterologous comparison， there was a significant difference in the functional connection strength between left M1 and right M1 in the left stroke group or the right stroke group when compared with that in the healthy group (P<0.05)， suggesting that the functional connection strength between the two hemispheres of the left or right stroke group， that is, between the healthy and affected hemispheres， was significantly weakened compared with the healthy group. In addition， compared with the healthy group， the functional connection strength between left and right hemisphere PFC in the right stroke group exhibited significant difference (P<0.05)，while no significant difference in the left stroke group (P>0.05). There was no significant difference in functional connectivity between the other ROI functional intervals (P>0.05).
Conclusion： In the study of resting brain functional connectivity using functional near-infrared brain functional imaging， the average intensity of whole brain functional connectivity in the left and right stroke groups is lower than that in the healthy group. The functional connection of M1 area on the affected side in the left stroke group was lower than that in the healthy group. For the functional connection between the left and right hemispheres， the functional connection of M1 area on both hemispheres in the left or right stroke group decreased， and the functional connection of PFC area on both hemispheres in the right stroke group decreased. |
| Keywords:functional near-infrared spectroscopy brain network resting-state functional brain connectivity |
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