| 李 策,李浩正,朱玉连,胡瑞萍,张丽君,田 闪,沈 莉,谢鸿宇,姜汶伶,范晨雨,吴 毅,吴军发.运动能力不同的脑卒中患者脑静息态功能连接的特征分析[J].中国康复医学杂志,2022,(5):606~610 |
| 运动能力不同的脑卒中患者脑静息态功能连接的特征分析 点此下载全文 |
| 李 策 李浩正 朱玉连 胡瑞萍 张丽君 田 闪 沈 莉 谢鸿宇 姜汶伶 范晨雨 吴 毅 吴军发 |
| 复旦大学附属华山医院康复医学科，上海市，200040 |
| 基金项目：国家重点研发计划(2018YFC2001700)；上海市卫计委项目(201840225)；上海市科学技术委员会项目(20412420200，18411962300，19411968700)；上海市临床重点专科项目(shslczdzk702) |
| DOI：10.3969/j.issn.1001-1242.2022.05.006 |
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| 摘要： |
| 摘要
目的：用功能性近红外光谱技术(functional near-infrared spectroscopy，fNIRS)观察运动功能不同的脑卒中患者脑静息态功能连接情况，可为临床制定非侵入性脑刺激方案提供治疗靶点。
方法：应用fNIRS基于氧合血红蛋白和脱氧血红蛋白，观察46例脑卒中后偏瘫患者及21例健康对照组静息状态下脑区之间的功能连接情况。
结果：基于氧合血红蛋白情况下，严重运动障碍组同源感觉运动网络(sensorimotor network，SEN)及腹侧注意网络(ventral attention network，VAN)功能连接强度与健康对照组相比有显著降低(P<0.05)；严重运动障碍组非同源脑网络(SEN-VAN，SEN-默认模式网络(default mode network，DMN)，SEN-额顶网络（frontoparietal network，FPN)，VAN-DMN）功能连接强度与健康对照组相比有显著降低（P<0.05)。基于脱氧血红蛋白情况下，轻度运动障碍组同源脑网络（VAN）功能连接强度与健康对照组相比有显著性降低(P<0.05)，严重运动障碍组同源脑网络(SEN，VAN，DMN）功能连接强度与健康对照组相比有显著降低（P<0.05)；严重运动障碍组非同源脑网络(DMN-VAN，VAN-FPN，FPN-DMN）功能连接强度与健康对照组相比有显著降低（P<0.05)。
结论：fNIRS适用于全脑静息态功能连接研究，重度功能障碍的脑卒中患者同源、非同源网络的功能连接强度显著降低。 |
| 关键词：功能性近红外光谱技术 运动功能 功能连接 |
| Characteristic analysis of functional connectivity in stroke patients with different motor performance Download Fulltext |
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| Huashan Hospital， Fudan University， Shanghai， 200040 |
| Fund Project: |
| Abstract: |
| Abstract
Objective： Functional near-infrared technique (fNIRS) was used to observe the functional connectivity in the resting state of the brain in stroke patients with different motor performance， which could provide a therapeutic target for the clinical development of non-invasive brain stimulation programs.
Method： fNIRS was used to observe the functional connections between brain regions in 46 patients with post-stroke hemiplegia and 21 healthy controls in resting state based on oxyhemoglobin and deoxyhemoglobin.
Result： Based on oxyhemoglobin，the functional connectivity intensity of homologous sensorimotor network(SEN) and ventral attention network(VAN) was significantly decreased in the severe dyskinesia group， compared with the healthy control group(P<0.05). The functional connections of non-homologous brain networks(SEN-VAN，SEN-default mode network(DMN)，SEN- frontoparietal network(FPN)，VEN-DMN) in the severe dyskinesia group were significantly decreased， compared with the healthy control group(P<0.05). Based on deoxyhemoglobin，the functional connectivity strength of homologous brain network(VAN) in the mild dyskinesia group was significantly decreased， compared with the healthy control group(P<0.05)，the functional connectivity intensity of homologous brain network(SEN，VAN，DMN) of severe dyskinesia group was significantly decreased, compared with the healthy control group(P<0.05). The functional connectivity intensity of non-homologous brain networks(DMN-VAN，VAN-FPN，FPN-DMN) in the severe dyskinesia group was significantly decreased, compared with the healthy control group(P<0.05).
Conclusion： fNIRS is suitable for the study of functional connectivity in the resting state of the whole brain， and the functional connectivity intensity of homologous and non-homologous networks significantly decreased in stroke patients with severe dysfunction. |
| Keywords:functional near-infrared spectroscopy motor function functional connectivity |
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