| 王德正,王 威,徐舫舟,朱健群,岳寿伟,张 杨.伴发神经病理性疼痛的脊髓损伤患者脑电生物标记分析[J].中国康复医学杂志,2022,(11):1463~1470 |
| 伴发神经病理性疼痛的脊髓损伤患者脑电生物标记分析 点此下载全文 |
| 王德正 王 威 徐舫舟 朱健群 岳寿伟 张 杨 |
| 山东大学齐鲁医院康复科，山东省济南市，250012 |
| 基金项目：山东省自然科学基金面上项目（ZR202102200383）；2019年山东省高等学校青创科技计划（2019KJN010）；济南市“新高校20条”引进创新团队项目（2021GXRC071） |
| DOI：10.3969/j.issn.1001-1242.2022.11.005 |
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| 摘要
目的：定量评价伴有神经病理性疼痛的脊髓损伤（spinal cord injury， SCI）患者在静息和执行运动想象任务时脑电信号的特征，识别脑电生物标记。
方法：选取2020年6月—2021年12月在山东大学齐鲁医院住院治疗的SCI患者，采用利兹神经病理性症状和体征评分（Leeds assessment of neuropathic symptoms and signs， LANSS）评定患者的疼痛程度，分为有疼痛的PWP（the patients with pain）组，无疼痛的PNP（the patients without pain）组，健康人作为AB对照组（均n=9）。记录受试者静息态左手、右手和双脚运动想象任务态脑电信号。通过改进的S变换，分别计算出θ（4—8Hz）、α（8—12Hz）与β（13—30Hz）频带的功率谱密度（power spectra density， PSD）和θ/α值。比较3组患者脑电信号特征，计算与LANSS评分的相关性。
结果：在睁眼静息状态下，PWP组多个信道的θ/α值明显高于PNP组与AB组（均P<0.05）。运动想象时，PNP组多个信道的α和β频带PSD值明显高于PWP组和AB组（均P<0.05）；在静息状态下及运动想象时，疼痛患者多个信道α、θ频带PSD值和θ/α值与疼痛评分有相关性（均P<0.05）。
结论：脑电图的θ/α值可作为SCI后神经病理性疼痛的生物标记，且可作为疼痛严重程度的评价指标。 |
| 关键词：脊髓损伤 神经病理性疼痛 脑电检测 生物标记 运动想象 |
| Investigation of EEG bio-markers in spinal cord injury patients with neuropathic pain Download Fulltext |
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| Department of Physical Medicine and Rehabilitation， Qilu Hospital， Cheeloo College of Medicine， Shandong University， Jinan， 250012 |
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| Abstract: |
| Abstract
Objective： The objective of this study was to quantitatively evaluate the characteristics of electroencephalogram（EEG） during resting or motor imagery tasks in spinal cord injury（SCI） patients with or without neuropathic pain and to identify the EEG biomarkers.
Method： The inpatients with SCI from June 1， 2020 to December 30， 2021 in Qilu Hospital of Shandong University were selected and their pain degree was evaluated by Leeds assessment of neuropathic symptoms and signs（LANSS）. The patients were divided into the patients with pain（PWP） group （n=9） and the patients without pain（PNP） group （n=9）. Nine matched healthy subjects were recruited as a control group（AB）. A 64-channel EEG recording system was used to record the EEG signal at the resting state or motor imagery task state. The modified S transform is carried out and the obtained data is normalized. The power spectra density （PSD） of θ （4—8Hz）， α （8—12Hz）， β （13—30Hz） bands， and θ/α ratio were calculated respectively. The difference in EEG signal characteristics among the three groups was compared. The correlation with the LANSS score was calculated.
Result： In the PWP group， the event-related desynchronization （ERD）/event-related synchronization （ERS） phenomenon was observed in α， β， and θ bands in the motor area and premotor area during cue-based motor imagery. The θ/α ratio of multiple channels in the PWP group was significantly higher than those in the PNP group and AB group （all P<0.05）. The PSD values of α and β bands in the PNP group were significantly higher than those in the PWP group and AB group （all P<0.05）， with no significant difference between the PWP group and AB group （all P>0.05）. In spontaneous and motor imagery-induced EEG， the PSD in α， θ band and θ/α ratio showed significant relevance with LANSS Score in patients with pain （all P<0.05）.
Conclusion： The EEG θ/α ratio can be used as a biomarker for neuropathic pain after SCI. It can be used as an evaluation index of pain severity. |
| Keywords:spinal cord injury neuropathic pain electroencephalogram bio-markers motor imagery |
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