| 张晨晨,陈秀恩,郑洁皎,江紫辉,伍 勰.基于功能性近红外光谱技术的不同吞咽任务态前额叶皮质功能研究[J].中国康复医学杂志,2023,(10):1372~1378 |
| 基于功能性近红外光谱技术的不同吞咽任务态前额叶皮质功能研究 点此下载全文 |
| 张晨晨 陈秀恩 郑洁皎 江紫辉 伍 勰 |
| 复旦大学附属华东医院康复医学科，上海市，200040 |
| 基金项目：上海市卫健委面上项目（202240256，201640093）；华东医院骨干人才培养计划资助项目（HDGG2017007）；国家重点研发计划项目（2020YFC2008700；2020YFC2008705）；上海康复医学临床医学研究中心计划项目（21MC1930200） |
| DOI：10.3969/j.issn.1001-1242.2023.10.007 |
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| 摘要： |
| 摘要
目的：采用功能性近红外光谱技术（functional near-infrared spectroscopy， fNIRS）研究不同吞咽任务态前额叶皮质激活情况。
方法：纳入19例健康成人受试，在fNIRS采集过程中执行经注射器小口吞咽及经吸管连续吞咽任务，分析不同吞咽任务态前额叶皮质激活模式的差异。
结果：在执行小口吞咽任务态，前额叶中显著激活的亚区为双侧的腹外侧前额叶皮层（ventrolateral prefrontal， VLPFC）；执行连续吞咽任务态，前额叶中显著激活的亚区为右侧腹外侧前额叶皮层、双侧的背外侧前额叶皮层（dorsolateral prefrontal cortex， DLPFC）及双侧的眶额皮层（orbitofrontal cortex， OFC），其中右侧额极区（frontopolar prefrontal cortex， FPC）激活呈边缘化显著。经配对t检验发现，连续吞咽任务在右侧背外侧前额叶皮层（DLPFC）及右侧额极区（FPC）中的激活程度明显高于小口吞咽任务（P<0.05）。
结论：fNIRS可应用于吞咽相关的脑功能研究。前额叶参与吞咽过程，并且以接近自然状态下的方式吞咽时会激活更多的前额叶亚区。 |
| 关键词：吞咽 功能性近红外光谱技术 前额叶 认知 |
| The study of prefrontal cortex function in different swallowing task based on functional near-infrared spectroscopy Download Fulltext |
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| Department of Rehabilitation Medicine， Hua-dong Hospital Affiliated to Fudan University， Shanghai， 200400 |
| Fund Project: |
| Abstract: |
| Abstract
Objective： To investigate the prefrontal cortex activation during different swallowing tasks by using the functional near-infrared spectroscopy （fNIRS）.
Method： Nineteen healthy adults were enrolled to perform two functional swallowing tasks during the fNIRS measure, including a single sip of 3ml of water via syringe and continuous straw drinking. The differences in prefrontal cortex activation patterns under different swallowing tasks were analyzed.
Result： During the single-sip swallowing task， the bilateral ventrolateral prefrontal cortex （VLPFC） was significantly activated. During the continuous swallowing task， the right ventrolateral prefrontal cortex （R-VLPFC）， bilateral dorsolateral prefrontal cortex （DLPFC） and bilateral orbitofrontal cortex （OFC） were significantly activated， and the activation of the right frontopolar prefrontal cortex （R-FPC） was marginally significant. The paired t test showed that the activation degree of the continuous swallowing in the right dorsolateral prefrontal cortex （R-DLPFC） and the right frontopolar prefrontal cortex （R-FPC） was significantly higher than that of single-sip swallowing （P<0.05）.
Conclusion： The fNIRS can be applied to study brain function related to swallowing. The prefrontal lobe is involved in swallowing，with more activation of the prefrontal subregion when swallowing in a more natural manner. |
| Keywords:swallowing functional near-infrared spectroscopy prefrontal lobe cognition |
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