| 蒋孝翠,刘 臻,苏清伦,赵 秦,李海宁.基于镜像神经元理论的动作观察疗法对轻、中度阿尔茨海默病患者语言功能的影响[J].中国康复医学杂志,2023,(10):1393~1397 |
| 基于镜像神经元理论的动作观察疗法对轻、中度阿尔茨海默病患者语言功能的影响 点此下载全文 |
| 蒋孝翠 刘 臻 苏清伦 赵 秦 李海宁 |
南京医科大学康达学院第一附属医院(连云港市第一人民医院)
，江苏省连云港市，222000 |
| 基金项目：连云港市老龄健康面上科研项目（L202106） |
| DOI：10.3969/j.issn.1001-1242.2023.10.010 |
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| 摘要： |
| 摘要
目的：研究基于镜像神经元理论的动作观察疗法对轻、中度阿尔茨海默病患者语言功能的影响。
方法：采用对照试验研究，选取轻、中度阿尔茨海默病患者40例，按照随机数字表法将40例阿尔茨海默病患者随机分为试验组20例、对照组20例。两组患者均采用强化语言训练，每次30min，对照组2次/d，试验组1次/d，每周治疗6天，共8周。试验组在对照组基础上增加基于镜像神经元理论的动作观察疗法，每次30min，每周6次，共8周。于治疗前、治疗8周后采用中康汉语标准失语症检查量表（China Rehabilitation Research Center Aphasia Examination， CRRCAE）、波士顿诊断性失语症测验（Boston Diagnostic Aphasia Test， BADE）、血清脑源性神经营养因子（brain-derived neurotrophic factor， BDNF）评价治疗效果。
结果：治疗前，两组患者的语言功能、BDNF水平比较，差异无显著性意义（P>0.05）。治疗后，两组患者的语言功能、BDNF水平均较组内治疗前明显提高（P<0.05），且治疗后试验组听理解、命名、列举、阅读、书写、BDNF水平、治疗有效率明显优于对照组（P<0.05）。
结论：基于镜像神经元理论的动作观察疗法可以改善轻、中度阿尔茨海默病患者语言功能。 |
| 关键词：镜像神经元 动作观察疗法 阿尔茨海默病 语言功能 |
| Effects of action observation therapy based on mirror neuron theory on language function in patients with mild and moderate Alzheimer's disease Download Fulltext |
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| The First Affiliated Hospital of Kangda College of Nanjing Medical University， The First People's Hospital of Lianyungang， Jiangsu， 222000 |
| Fund Project: |
| Abstract: |
| Abstract
Objective： To study the action observation therapy based on the theory of the mirror neurons on the language function of patients with mild and moderate Alzheimer's patients.
Method： A controlled trial study was conducted, and 40 patients with mild and moderate Alzheimer's disease were selected and randomly divided into experimental group (n=20) and control group (n=20) according to the random number table. Both groups received intensive language training， 30 minutes each time， 6 times a week for a total of 8 weeks. On the basis of the control group， the experimental group was added with the action observation therapy based on mirror neuron theory with the same frequency and duration. The China Rehabilitation Research Center Aphasia Examination（CRRCAE）， Boston Diagnostic Aphasia Test （BADE） and serum brain-derived neurotrophic factor （BDNF）was used to evaluate the therapeutic effect before and after the whole treatment.
Result： Before treatment， there was no significant difference in language function and BDNF level between the two groups （P>0.05）. After treatment， the language function and BDNF level of patients in the two groups were significantly improved compared with those before treatment （P<0.05）； the level of listening comprehension， naming， enumeration ， reading， writing， BDNF and treatment efficiency in the experimental group were significantly better than those in the control group （P<0.05）.
Conclusion： Action observation therapy based on mirror neuron theory can improve language function in patients with mild and moderate Alzheimer's disease. |
| Keywords:mirror neuron action observation therapy Alzheimer's disease language function |
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