| 窦 丽,张 钧.有氧运动对高血压大鼠血浆6-酮-前列腺素F1α、血栓素B2含量和PGI2／TXA2系统的影响[J].中国康复医学杂志,2008,23(3):251~253 |
| 有氧运动对高血压大鼠血浆6-酮-前列腺素F1α、血栓素B2含量和PGI2／TXA2系统的影响 点此下载全文 |
| 窦 丽 张 钧 |
| 南京林业大学体育部,210037 |
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| DOI： |
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| 摘要： |
| 摘要 目的：探讨运动对自发性高血压大鼠（SHR）血浆6-酮-前列腺素F1α（6-keto-PGF1α）、血栓素B2（TXB2）含量和前列环素/血栓烷A2（PGI2／TXA2）系统的影响。方法：雄性SHR大鼠随机分为对照组和运动组。运动组大鼠进行60min/d无负重游泳运动，每周5d，实验共10周。实验期间，每2周测定大鼠血压，10周后，采用放射免疫非平衡法测定血浆TXB2和6-keto-PGF1α含量。结果：对照组大鼠血压较试验前显著性升高（P<0.01），而运动组大鼠血压较试验前显著性下降。与对照组相比，运动组大鼠血压、TXB2含量显著下降（P<0.01），血浆6-keto-PGF1α含量，6-keto-PGF1α／TXB2比值显著提高（P<0.01）。结论：适宜的运动可以降低SHR大鼠血压水平，改善PGI2／TXA2失衡，预防高血压及血栓形成。
关键词 有氧运动; 自发性高血压大鼠; 6-酮-前列腺素F1α; 血栓素B2; PGI2／TXA2系统
中图分类号: R544.1,R493 文献标识码：A 文章编号：1001-1242(2008)-03-0251-03 |
| 关键词：有氧运动 自发性高血压大鼠 6-酮-前列腺素F1α 血栓素B2 PGI2／TXA2系统 |
| Effects of training on the content of plasma 6-keto-PGF1α and the TXB2，and PGI2／TXA2 system in spontaneously hypertensive rats Download Fulltext |
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| Dept. of P.E. Nanjing Forestry University, Nanjing, 210037 |
| Fund Project: |
| Abstract: |
| Objective: To observe the effect, of training on the content of plasma 6-keto-PGF1α and the TXB2, and the PGI2／TXA2 balance in spontaneously hypertensive rats(SHR). Method: Male SHR are randomly divided into the control group and swimming exercises group. After 10 weeks of training, plasma TXB2, 6-keto-PGF1α content and resting blood pressure level were measured．Result: Resting blood pressure level of exercise group obviously descended，plasma 6-keto-PGF1α, 6-keto-PGF1α／TXB2 ascended obviously as compared with that of control group. Conclusion: Proper training can descend the resting blood pressure level of SHR，and obtain better balance between PGI2 and TXA2 to prevent developing of hypertension and thrombosis |
| Keywords:aerobic exercises spontaneously hypertensive rats 6-keto-PGF1α TXB2 PGI2／TXA2 system |
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