| 袁 华,龙 华,牟 翔,李 玲,张美霞,葛雪松,刘 静,瞿丽莉,陈景藻.8Hz次声对大鼠学习记忆能力和神经元再生的影响[J].中国康复医学杂志,2008,23(5):385~387 |
| 8Hz次声对大鼠学习记忆能力和神经元再生的影响 点此下载全文 |
| 袁 华 龙 华 牟 翔 李 玲 张美霞 葛雪松 刘 静 瞿丽莉 陈景藻 |
| 第四军医大学西京医院康复与理疗科, 西安，710032 |
| 基金项目：全军医学科学技术研究“十五”计划指令性课题(OlL071) |
| DOI： |
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| 摘要： |
| 目的：观察次声作用对大鼠学习记忆能力和脑内神经元再生的影响。方法：将36只SD大鼠随机分为对照组和8Hz 130dB次声作用组。次声作用组大鼠暴露于8Hz 130dB次声，分别作用1、2和4周；对照组大鼠除无次声作用外，余处理均同于次声作用组。各组大鼠实验结束后进行水迷宫测评后取脑，抗Ki-67免疫组化显示脑内脑室下带 (subventricular zone，SVZ)和海马齿状回颗粒层下增生带(subgranular proliferative zone，SGZ)中神经细胞再生情况的变化。结果：8Hz 130dB次声作用从第2周开始增生的神经细胞数目开始减少，到第4周时增生期的神经细胞数目比对照组大鼠减少，同时大鼠表现出水迷宫测评中找到站台的潜伏期延长。结论：8Hz 130dB次声慢性作用后大鼠引起脑内尤其海马SGZ中增生的神经细胞数目减少，这可能是次声作用引起学习记忆功能障碍的原因之一。 |
| 关键词：次声 脑室下带 海马齿状回颗粒层下增生带 学习记忆能力 增生 |
| The effect of 8Hz infrasound on the learning and memory ability and proliferation in rats′ brain Download Fulltext |
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| Department of Physiotherapy and Rehabilitation, Xijing Hospital, the Fourth Military Medical University, 710032 |
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| Abstract: |
| Objective: To study the effect of 8Hz infrasound with different duration (1, 2 and 4 weeks) on the proliferation in rats′ brain. Method:Thirty-six SD rats were randomly divided into 1, 2 and 4 weeks infrasound exposure groups and control group (n=12). Infrasound exposure groups were exposed to 8Hz 130dB infrasound, 2h/d for 1, 2 and 4 weeks respectively. The control rats were treated as well as the infrasound exposure group except for the infrasound exposure. At the last 3 days of the treatment duration, rats were applied for Morris water maze test. After then their brains were removed and anti-Ki67 immunohistochemical staining was used to check the proliferation in rats′ brain. Result: After 2 weeks exposure to 8Hz 130dB infrasound, the performance in water maze began to be impaired. The Ki-67 positive cells in SGZ decreased the top decrease occurred in 4th week. Conclusion: 8Hz 130dB infrasound could down regulate the proliferation in the SGZ, which may be involved in the impairment of learning and memory. |
| Keywords:infrasound subventricular zone subgranular proliferative zone learning and memory ability proliferation |
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