| 李 娜,高俊淑,李 阔,陈景红,贾子善.不同环境设置对局灶性脑梗死大鼠梗死灶周围Syn表达的影响[J].中国康复医学杂志,2009,24(3):213~215 |
| 不同环境设置对局灶性脑梗死大鼠梗死灶周围Syn表达的影响 点此下载全文 |
| 李 娜 高俊淑 李 阔 陈景红 贾子善 |
| 河北省人民医院神经二科，石家庄，050051 |
| 基金项目：河北省卫生厅资助课题（03025） |
| DOI： |
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| 摘要： |
| 目的：观察不同环境对局灶性脑梗死大鼠梗死灶周围突触膜糖蛋白表达的影响。方法：雄性SD大鼠95只，采用电凝法造成右侧大脑中动脉阻断（MCAO）模型后，随机分为独居组（n=20），社交组（n=30），探索学习组（n=20），丰富环境组（n=20），假手术对照组（n=5）。于不同时点分批处死大鼠，用免疫组化染色观察梗死灶周围皮质Syn阳性表达。结果：MCAO后梗死灶周围皮质Syn阳性表达均高于假手术对照组，并且随时间的推移，其表达进一步增高。探索学习组、丰富环境组于MCAO术后各时间点Syn表达均明显优于独居组和社交组(P<0.05,P<0.01)；探索学习组在3、4周表达高于丰富环境组(P<0.05)；社会交往组表达高于独居组(P<0.05)。结论：丰富环境；探索学习及社会交往均能促进梗死灶周围Syn的表达。 |
| 关键词：丰富环境 探索学习 脑梗死 大鼠 突触膜糖蛋白 |
| The effects of different environmental interventions on Syn expressions in peri-infarction cortex of rats after unilateral local cerebral infarction Download Fulltext |
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| Rehabilitation Center, Hebei Provincial People′s Hospital, Shijiazhuang, 050051 |
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| Abstract: |
| Objective: To observe the effects of different environmental interventions on synaptophysin(Syn) expressions in peri-infarction cortex of rats after unilateral local cerebral infarction. Method: After the models of MCAO were established by electric coagulation successfully, 95 male rats were randomly divided into 5 groups: individual living group(n=20), social communication group(n=30), learning group(n=20) , enriched environment group(n=20) and sham operated group(n=5). The rats were randomly sacrificed at different time points. The expressions of Syn in peri-infarction cortex were examined by immunohistochemistry staining. Result: After MCAO, the expressions of Syn in peri-infarction cortex upregulated significantly comparing with that in sham group at any time points. The expressions of Syn in learning group and enriched environment group were higher than that in individual living group and social communication group at any time points after MCAO（P<0.05 or P<0.01). It were higher in learning group than that in enriched environment group on day14 and 21(P<0.05); and also were higher in social communication group than that in individual living group (P<0.05). Conclusion: Learning, enriched environment and social communication after MCAO could up-regulate the expressions of Syn in peri-infarction regions. |
| Keywords:enriched environment learning cerebral infarction rat synaptophysin |
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