| 李 川,范建中,吴红瑛,魏 轶.低声压级次声对大鼠脑缺血再灌注损伤的影响[J].中国康复医学杂志,2009,24(5):419~422 |
| 低声压级次声对大鼠脑缺血再灌注损伤的影响 点此下载全文 |
| 李 川 范建中 吴红瑛 魏 轶 |
| 南方医科大学南方医院康复医学科，广东，广州，510515 |
| 基金项目： |
| DOI： |
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| 摘要： |
| 目的：研究低声压级次声对大鼠局灶性脑缺血再灌注损伤的影响。方法：用线栓法制备右侧大脑中动脉脑缺血模型。以Infrasound 8TM次声治疗仪产出的次声作为处理因素。将64只大鼠随机分为3组，分别为假手术组（n=16）、模型组（n=16）、次声组（n=32），次声组按每天作用时间分为20min组及120min组，每组16只大鼠。动态观察（第2小时、1天、3天和7天）各组神经功能状态，7d后大鼠断头取脑，每组中的8只用于HE染色，另外8只用于TTC染色以测定脑梗死相对体积。结果：与模型组相比，次声120mi |
| 关键词：次声 局灶性脑缺血 缺血再灌注损伤 大鼠 |
| Effects of infrasound with low sound pressure level on rats with cerebral ischemia-reperfusion injury Download Fulltext |
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| Department of Rehabilitation Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515 |
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| Abstract: |
| Objective：To study the effects of infrasound with low sound pressure level on rats with cerebral ischemia-reperfusion injury. Method: Focal cerebral ischemia model in rats was produced by 2h occlusion of middle cerebral artery. Infrasound generated by infrasound 8TM device was treated as treatment factor. Sixty-four SD rats were divided into three groups: sham group(n=16), model group (n=16)and infrasound group(n=32); the latter group was subdivided into 20- and 120-min infrasound group, with 16 rats in each group. Neurological symptoms were assessed at the 2nd h、1st d、3rd d and 7th d respectively. These rats were sacrificed at the 7th d and rats′ brains were taken out. Half of each group was used in HE stain, another half was used in calculating cerebral ischemia relative volume by TTC stain. Result: Compared with model group, in 120-min infrasound group neurological symptoms improved significantly(P<0.05), the cerebral ischemia volume was significantly smaller (P<0.01), and pathological damages were also lessen. Conclusion: Infrasound with low sound pressure level（120min/d,7d） played neuroprotective role in cerebral ischemia -reperfusion injury. |
| Keywords:infrasound focal cerebral ischemia ischemia-refusion rat |
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