| 邓轩赓,陈建庭,冯 鹰.复合振动对去势骨质疏松大鼠骨强度的作用[J].中国康复医学杂志,2009,24(10):884~886 |
| 复合振动对去势骨质疏松大鼠骨强度的作用 点此下载全文 |
| 邓轩赓 陈建庭 冯 鹰 |
| 四川省骨科医院脊柱骨科，成都，610041 |
| 基金项目：广东省自然科学基金（06024394） |
| DOI： |
| 摘要点击次数: 2457 |
| 全文下载次数: 2261 |
| 摘要： |
| 目的：观察复合振动骨质疏松大鼠骨强度的影响。方法：4.5月龄SD雌性未育大鼠24只，随机分为对照组和两个实验组。卵巢摘除法骨质疏松造模成功后，实验组各自接受不同的复合振动，分别测大鼠腰椎、股骨骨密度，胫骨骨微结构，腰椎、股骨力学性能。结果：两振动组大鼠腰椎、股骨骨密度均有明显增加,腰椎：0.0055±0.0126g/cm2,0.0132±0.0078g/cm2,股骨：0.0078±0.0081g/cm2,0.0145±0.0053g/cm2，但仅振动2组骨结构（小梁骨数量、间距、连接密度、骨体积分数）和骨极限强度有显著性改善。结论：特定复合振动可以增强去势骨质疏松大鼠骨强度，与同类研究比较可降低振动强度，在治疗骨质疏松方面有应用前景。 |
| 关键词：骨质疏松 骨强度 复合振动 |
| The effect of compound vibration on bone strength in ovariectomized SD rat osteoporosis models Download Fulltext |
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| Dept. of Spine Sichuan Orthopaedics Hospital, Chengdu, 610041 |
| Fund Project: |
| Abstract: |
| Objective： To observe the effect of compound vibration on bone strength in ovariectomized SD rats. Method：Twenty-four ovariectomized SD rats of 4.5-months were randomly divided into three groups(n=8): one control group and two vibration groups. The vibration groups received different vibrations respectively. The lumbar and femur bone mineral density(BMD), tibia bone microarchitecture, lumbar and femur bone biomechanical property were measured. Result：After compound vibration intervention, the gain of lumbar and femur BMD in two vibration groups improved significantly compared with control. L：0.0055±0.0126g/cm2,0.0132±0.0078g/cm2; F：0.0078±0.0081g/cm2,0.0145±0.0053g/cm2. But only vibration group 2 showed significant improvement on some parameters of bone microarchitecture (trabecular number, trabecular separation, connectivity density and bone volume fraction) and bone biomechanics(ultimate strength). Conclusion： Specified compound vibration could enhance bone strength of ovariectomized rats with osteoporosis. Compound vibration could reduce the vibration magnitude compared with the other relative research, which led to the perspective of osteoporosis treatment or rehabilitation in clinic. |
| Keywords:osteoporosis bone strength compound vibration |
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