| 杨 拯,何秋兰,唐 伟,谢光科,李巧惠,丁红霞,李向莲,包 旭,陈建敏,田 芸,张 晓.维生素E联合单唾液酸神经节苷脂对脊髓损伤大鼠运动功能恢复的影响[J].中国康复医学杂志,2010,25(6):536~539 |
| 维生素E联合单唾液酸神经节苷脂对脊髓损伤大鼠运动功能恢复的影响 点此下载全文 |
| 杨 拯 何秋兰 唐 伟 谢光科 李巧惠 丁红霞 李向莲 包 旭 陈建敏 田 芸 张 晓 |
| 成都医学院基础医学院实验技术教研室，成都，610081 |
| 基金项目：四川省科技厅课题基金（2008SZ0053）；成都医学院实验室开放实验基金（KF200936）；成都医学院创新性实验项目基金（CX200907） |
| DOI： |
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| 摘要
目的：观察维生素E(Vit E)联合单唾液酸神经节苷脂（GM1）对脊髓损伤（SCI）大鼠运动功能恢复的影响。
方法：健康成年SD大鼠48只，采用Allen法（10g×12.5mm）在T9造成急性脊髓损伤动物模型。动物随机分为4组：对照组（A组）、VitE治疗组（B组）、GM1治疗组（C组）和VitE+1/2GM1治疗组（D组），每组12只。伤后第1天、第7天和第14天分别用BBB评分和斜板试验观察大鼠运动功能的恢复情况。
结果：大鼠SCI后B、C、D组BBB评分和斜板试验优于对照组，第1天、第7天 BBB评分和斜板试验D组明显优于B、C组（P＜0.05）。
结论：大鼠脊髓损伤后早期使用VitE联合GM1对其运动功能的恢复有促进作用，效果优于VitE或GM1单独用药。 |
| 关键词：单唾液酸神经节苷脂 维生素E 脊髓损伤 运动功能 |
| Effects of vitamin E combined with monosialoganglioside on the recovery of motor function after spinal cord injury in rats Download Fulltext |
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| Department of Experimental Technology of Chengdu Medical College,Chengdu,610081 |
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| Abstract: |
| Abstract
Objective：To investigate the effects of vitamin E(VitE) combined with monosialoganglioside(GM1) on the recovery of motor function after spinal cord injury(SCI) in rats.
Method：Forty-eight healthy adult rats were randomly divided into A(control),B(VitE),C(GM1) and D(VitE+1/2GM1) groups. Each group had 12 rats. SCI model was made by Allen′s mode(10g×12.5mm) on spinal cord T9 extradually. At the 1st d，7th d and 14th d after SCI,the recovery of motor function after SCI in rats were assessed with Basso-Beattie-Bresnahan(BBB)scale and tilt board test.
Result：After SCI, BBB scores and tilt board test in group B,C and D were better than those in group A; and those in group D were better than those in group B and C. There were significant differences at day 1 and 7 after SCI in group D and B,C(P＜0.05).
Conclusion： Early application of VitE combined with GM1 can promote the recovery of motor function after SCI in rats，and is superior to VitE or GM1 alone. |
| Keywords:monosialoganglioside vitamin E spinal cord injury motor function |
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