| 李卫平,蹇 睿,胥方元.超声波对实验性兔膝骨关节炎软骨细胞基质金属蛋白酶-1表达的影响[J].中国康复医学杂志,2011,26(10):911~914 |
| 超声波对实验性兔膝骨关节炎软骨细胞基质金属蛋白酶-1表达的影响 点此下载全文 |
| 李卫平 蹇 睿 胥方元 |
| 四川省泸州医学院附属医院康复科，泸州，646000 |
| 基金项目： |
| DOI： |
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| 摘要： |
| 摘要
目的：探讨超声波治疗对兔膝骨关节炎（KOA）模型软骨细胞基质金属蛋白酶-1（MMP-1）表达的影响。
方法：30只新西兰大白兔随机分为正常对照组、模型组和超声波治疗组，每组10只。将模型组和超声波治疗组的兔左膝于伸直位石膏固定6周制作KOA模型。造模后超声波治疗组实施超声波治疗2周。8周后取各组软骨观察膝软骨病理学形态改变、MMP-1表达的变化。
结果：采用Mankin评分比较病理学形态改变，正常对照组与模型组、模型组与超声波治疗组间比较，差异均有显著性意义(P<0.01)。软骨免疫组化MMP-1测定，正常对照组与模型组、模型组与超声波治疗组间比较，差异均有显著性意义(P<0.01)。
结论：超声波能有效治疗膝骨性关节炎，其作用机制可能与减少软骨细胞MMP-1的含量而利于软骨细胞的修复有关。 |
| 关键词：骨关节炎 软骨细胞 超声波 基质金属蛋白酶-1 |
| The effect of ultrasonic therapy on expression of matrix-metalloproteinase-1 in cartilage cells of rabbit with knee osteoarthritis Download Fulltext |
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| Department of Rehabilitation Medicine, Affiliated Hospital of Luzhou Medical College, Luzhou, 646000 |
| Fund Project: |
| Abstract: |
| Abstract
Objective: To study the effect of ultrasound therapy on expression of matrix-metalloproteinase-1(MMP-1) in cartilage cells of rabbit with knee osteoarthritis(KOA).
Method: Thirty healthy New Zealand white rabbits were randomly divided into 3 groups: normal control group contained 10 rabbits, not modeling; the other 20 rabbits were randomly divided into model group and ultrasonic experimental group, being created osteoarthritis. The rabbits' left knees were fixed within plaster cast in stretch position for 6 weeks to created KOA models. Then ultrasonic, experimental group was given ultrasonic treatment for 2 weeks. After 8 weeks cartilage changes on pathological morphology and expression of MMP-1 were observed in all groups.
Result: By Mankin's score the severity of pathological lesion in model group was higher than that in normal control group and ultrasonic experimental group (P<0.01). The expression of MMP-1 in model group was higher than that in normal control group and ultrasonic experimental group, the difference was significant (P<0.01).
Conclusion: The ultrasonic treatment can effectively improve the rabbits' KOA, and its mechanism probably is correlated with reducing MMP-1 level in cartilage cells, which will be helpful for repairing cartilage cells. |
| Keywords:osteoarthritis cartilage cells ultrasound matrix metalloproteinase-1 |
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