| 王彦伟,王明金,卢学伟,黄丽敏,赵 斌.抗阻训练对老龄大鼠骨骼肌新生细胞核数量的影响[J].中国康复医学杂志,2012,27(6):504~509 |
| 抗阻训练对老龄大鼠骨骼肌新生细胞核数量的影响 点此下载全文 |
| 王彦伟 王明金 卢学伟 黄丽敏 赵 斌 |
| 河北师范大学，050090 |
| 基金项目：河北省自然科学基金资助项目（C2008000177），河北师范大学研究生科研基金资助项目（201002024） |
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| 摘要
目的：观察10周抗阻训练后老龄大鼠骨骼肌内细胞核数量的变化情况，及其合成能力加强。
方法：选取17月龄的SD大鼠40只，随机分为安静组、大、中、小负重训练组，每组10只，用5-溴脱氧尿嘧啶核苷（Brdu）对新生细胞核进行标记，通过免疫组织化学的方法对新生肌核的数量进行比较。
结果：新生肌核数量方面：大负荷组（7.5±4.2）和中负荷组（6.7±3.6），显著高于安静组（2.1±1.3）和小负荷组（5.1±2.6）。肌纤维内肌核平均数量大负荷组（3.2±0.6）和中负荷组（3.1±0.5），显著高于安静组（2.4±0.5）和小负荷组（2.8±0.6）。肌肉重量方面，中负荷的（10.6±1.3g）和大负荷（10.1±1.4g），显著高于安静组(8.2±1.2g)。
结论：抗阻训练能使骨骼肌的细胞核增加，进而使骨骼肌的力量和体积增大。 |
| 关键词：抗阻训练 骨骼肌 肌核 |
| Impact of resistant training on amount of nascent nuclei of aging rats' skeletal muscles Download Fulltext |
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| Hebei Normal University,Shijiazhuang,050024 |
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| Abstract: |
| Abstract
Objective: To observe the impact of 10-week resistant training on the amount of nascent nuclei of skeletal muscles in aging rats，and strengthening of it's synthesis ability.
Method: Forty SD rats(17 month old) were selected randomly divided into a quiet group as well as large, medium and low loading training groups, with 10 rats in each group. The nascent myonucle: were marked with 5-bromodeoxyuridine(Brdu). The amount of nascent myonuclei were compared with immunohistochemical method.
Result: The amounts of nascent myonuclei in large loading training group（7.5±4.2） and moderate loading training group（6.7±3.6）were significantly higher than that in control group （2.1±1.3）and low loading training group（5.1±2.6）. The average quantity of myonuclei in muscle fiber in large loading training group（3.2±0.6） and moderate loading training group（3.1±0.5） were significantly higher than that in control group （2.4±0.5）and low loading training group（2.8±0.6）. The weight of skeletal muscle in moderate loading training group（10.6±1.3g） and large loading training group（10.1±1.4g） were significantly higher than that in control group（8.2±1.2g）
Conclusion: Resistant training could increase the amount of skeletal muscle nuclei, so as to enhance the strength of skeletal muscle and the volume of skeletal muscle. |
| Keywords:resistant training skeletal muscle myonuclei |
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